Research ArticleGene Therapy

AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease

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Science Translational Medicine  11 Nov 2015:
Vol. 7, Issue 313, pp. 313ra180
DOI: 10.1126/scitranslmed.aac6191

Article Information

vol. 7 no. 313 313ra180

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 21, 2015
  • Accepted for publication October 23, 2015
  • .

Author Information

  1. Martin L. Katz1,*,
  2. Luis Tecedor2,*,
  3. Yonghong Chen2,*,
  4. Baye G. Williamson3,
  5. Elena Lysenko2,
  6. Fred A. Wininger3,,
  7. Whitney M. Young1,
  8. Gayle C. Johnson4,
  9. Rebecca E. H. Whiting3,
  10. Joan R. Coates3 and
  11. Beverly L. Davidson2,5,
  1. 1Department of Ophthalmology, University of Missouri, Columbia, MO 65212, USA.
  2. 2The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  3. 3Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
  4. 4Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
  5. 5Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  1. Corresponding author. E-mail: davidsonbl{at}email.chop.edu
    • * These authors contributed equally to this work.

    • Present address: Veterinary Specialty Services, Manchester, MO 63021, USA.

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