Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface

Beata Jarosiewicz; Anish A. Sarma; Daniel Bacher; Nicolas Y. Masse; John D. Simeral; Brittany Sorice; Erin M. Oakley; Christine Blabe; Chethan Pandarinath; Vikash Gilja; Sydney S. Cash; Emad N. Eskandar; Gerhard Friehs; Jaimie M. Henderson; Krishna V. Shenoy; John P. Donoghue; Leigh R. Hochberg

doi:10.1126/scitranslmed.aac7328

Research ArticleNEUROTECHNOLOGY

Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface

Beata Jarosiewicz¹,²,³,*,
Anish A. Sarma²,³,⁴,
Daniel Bacher³,⁴,
Nicolas Y. Masse¹,³,†,
John D. Simeral²,³,⁴,⁵,
Brittany Sorice⁵,
Erin M. Oakley⁵,‡,
Christine Blabe⁶,
Chethan Pandarinath⁶,⁷,⁸,
Vikash Gilja⁴,⁶,⁸,§,
Sydney S. Cash⁵,⁹,
Emad N. Eskandar¹⁰,
Gerhard Friehs¹¹,¶,
Jaimie M. Henderson⁶,⁷,
Krishna V. Shenoy⁷,⁸,¹²,¹³,¹⁴,
John P. Donoghue²,¹,³,⁴,∥ and
Leigh R. Hochberg²,³,⁴,⁵,⁹

¹Department of Neuroscience, Brown University, Providence, RI 02912, USA.
²Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, RI 02908, USA.
³Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA.
⁴School of Engineering, Brown University, Providence, RI 02912, USA.
⁵Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
⁶Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
⁷Stanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
⁸Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
⁹Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
¹⁰Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02115, USA.
¹¹Neurosurgery, Rhode Island Hospital, Providence, RI 02903, USA.
¹²Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
¹³Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
¹⁴Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

↵*Corresponding author. E-mail: beata{at}brown.edu

↵† Present address: Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.
↵‡ Present address: Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
↵§ Present address: Department of Electrical and Computer Engineering and Neurosciences Program, University of California, San Diego, La Jolla, CA 92093, USA.
↵¶ Present address: American Medical Center, Nicosia, Cyprus.
↵∥ Present address: Wyss Center for Bio and Neuro Engineering, 1202 Geneva, Switzerland.

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Science Translational Medicine 11 Nov 2015:
Vol. 7, Issue 313, pp. 313ra179
DOI: 10.1126/scitranslmed.aac7328

Beata Jarosiewicz

1Department of Neuroscience, Brown University, Providence, RI 02912, USA.

2Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, RI 02908, USA.

3Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA.

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For correspondence: beata@brown.edu

Anish A. Sarma

2Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, RI 02908, USA.

3Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA.

4School of Engineering, Brown University, Providence, RI 02912, USA.

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Daniel Bacher

3Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA.

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Nicolas Y. Masse

1Department of Neuroscience, Brown University, Providence, RI 02912, USA.

3Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA.

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John D. Simeral

2Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, RI 02908, USA.

3Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA.

4School of Engineering, Brown University, Providence, RI 02912, USA.

5Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Brittany Sorice

5Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Erin M. Oakley

5Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Christine Blabe

6Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

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Chethan Pandarinath

6Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

7Stanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.

8Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.

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Vikash Gilja

4School of Engineering, Brown University, Providence, RI 02912, USA.

6Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

8Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.

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Sydney S. Cash

5Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

9Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.

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Emad N. Eskandar

10Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02115, USA.

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Gerhard Friehs

11Neurosurgery, Rhode Island Hospital, Providence, RI 02903, USA.

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Jaimie M. Henderson

6Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

7Stanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.

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Krishna V. Shenoy

7Stanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.

8Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.

12Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.

13Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

14Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

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John P. Donoghue

2Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, RI 02908, USA.

1Department of Neuroscience, Brown University, Providence, RI 02912, USA.

3Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA.

4School of Engineering, Brown University, Providence, RI 02912, USA.

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Leigh R. Hochberg

2Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, RI 02908, USA.

3Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA.

4School of Engineering, Brown University, Providence, RI 02912, USA.

5Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

9Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.

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Individuals with tetraplegia are able to type self-paced for hours across multiple days using a self-calibrating point-and-click intracortical brain-computer interface.

Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface

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