Research ArticleCancer

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

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Science Translational Medicine  04 Nov 2015:
Vol. 7, Issue 312, pp. 312ra176
DOI: 10.1126/scitranslmed.aab1803

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Uncovering the FACTs in neuroblastoma

Neuroblastoma is a common pediatric cancer of the nervous system. It is often difficult to treat, and tumors with amplifications of the MYC oncogene are particularly aggressive. Carter et al. have identified a histone chaperone called FACT as a mediator of MYC signaling in neuroblastoma and demonstrated its role in a feedback loop that allows tumor cells to maintain a high expression of both MYC and FACT. The authors then used curaxins, which are drugs that inhibit FACT, to break the vicious cycle. They demonstrated that curaxins work in synergy with standard genotoxic chemotherapy to kill cancer cells and treat neuroblastoma in mouse models.

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