Research ArticleInfectious Disease
A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children
- Ruth A. Karron1,*,
- Cindy Luongo2,
- Bhagvanji Thumar1,
- Karen M. Loehr1,
- Janet A. Englund3,
- Peter L. Collins2 and
- Ursula J. Buchholz2
- 1Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
- 2RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 3Seattle Children’s Research Institute, University of Washington, Seattle, WA 98101, USA.
- ↵*Corresponding author. E-mail: rkarron{at}jhu.edu
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Science Translational Medicine 04 Nov 2015:
Vol. 7, Issue 312, pp. 312ra175
DOI: 10.1126/scitranslmed.aac8463
Vol. 7, Issue 312, pp. 312ra175
DOI: 10.1126/scitranslmed.aac8463
Ruth A. Karron
Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Cindy Luongo
RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Bhagvanji Thumar
Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Karen M. Loehr
Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Janet A. Englund
Seattle Children’s Research Institute, University of Washington, Seattle, WA 98101, USA.
Peter L. Collins
RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ursula J. Buchholz
RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
