Research ArticleInfectious Disease

A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children

See allHide authors and affiliations

Science Translational Medicine  04 Nov 2015:
Vol. 7, Issue 312, pp. 312ra175
DOI: 10.1126/scitranslmed.aac8463

Outflanking RSV

Respiratory syncytial virus (RSV) infection may lead to severe respiratory illness in young children. Researchers are working to develop a live attenuated vaccine, which would mimic the natural course of infection; however, inhibiting viral replication also limits the immune response. Now, Karron et al. report that a version of RSV lacking the M2-2 protein can induce immunity despite decreased vaccine virus shedding in young children. The lack of M2-2 resulted in decreased viral RNA replication needed for virus production while allowing gene transcription and antigen synthesis required for stimulating the immune response. Children who received the vaccine produced anti-RSV antibodies without medically attended illness in the subsequent RSV season, suggesting that this approach may provide protective immunity to RSV.

View Full Text

Stay Connected to Science Translational Medicine