Contents

Contents

• Focus

  • RSV vaccine: Beating the virus at its own game

    By Anne Moscona

    Science Translational Medicine04 Nov 2015 : 312fs44 Full AccessRestricted Access

    Rational design hijacks RSV’s own transcriptional machinery to pave the way for an innovative live attenuated vaccine (Karron et al., this issue).

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  • Liquid biopsy: Clues on prostate cancer drug resistance

    By Michael T. Schweizer, Emmanuel S. Antonarakis

    Science Translational Medicine04 Nov 2015 : 312fs45 Full AccessRestricted Access

    Analysis of tumor-derived cell-free DNA in blood yields insights into drug resistance in patients with castration-resistant prostate cancer (Romanel et al., this issue).

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• Research Articles

  • A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children

    By Ruth A. Karron, Cindy Luongo, Bhagvanji Thumar, Karen M. Loehr, Janet A. Englund, Peter L. Collins, Ursula J. Buchholz

    Science Translational Medicine04 Nov 2015 : 312ra175 Full AccessRestricted Access

    A live attenuated vaccine candidate for RSV may decrease viral replication while enhancing immunogenicity in children.

    • Editor's Summary
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    • Supplementary Materials

  • Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

    By Daniel R. Carter, Jayne Murray, Belamy B. Cheung, Laura Gamble, Jessica Koach, Joanna Tsang, Selina Sutton, Heyam Kalla, Sarah Syed, Andrew J. Gifford, Natalia Issaeva, Asel Biktasova, Bernard Atmadibrata, Yuting Sun, Nicolas Sokolowski, Dora Ling, Patrick Y. Kim, Hannah Webber, Ashleigh Clark, Michelle Ruhle, Bing Liu, André Oberthuer, Matthias Fischer, Jennifer Byrne, Federica Saletta, Le Myo Thwe, Andrei Purmal, Gary Haderski, Catherine Burkhart, Frank Speleman, Katleen De Preter, Anneleen Beckers, David S. Ziegler, Tao Liu, Katerina V. Gurova, Andrei V. Gudkov, Murray D. Norris, Michelle Haber, Glenn M. Marshall

    Science Translational Medicine04 Nov 2015 : 312ra176 Full AccessRestricted Access

    Histone chaperone FACT acts in a positive feedback loop with MYCN and is a therapeutic target in neuroblastoma.

    • Editor's Summary
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    • Supplementary Materials

  • Sodium channel Na_x is a regulator in epithelial sodium homeostasis

    By Wei Xu, Seok Jong Hong, Aimei Zhong, Ping Xie, Shengxian Jia, Zhong Xie, Michael Zeitchek, Solmaz Niknam-Bienia, Jingling Zhao, D. Marshall Porterfield, D. James Surmeier, Kai P. Leung, Robert D. Galiano, Thomas A. Mustoe

    Science Translational Medicine04 Nov 2015 : 312ra177 Full AccessRestricted Access

    Blocking Na_x expression improves scarring and atopic dermatitis–like symptoms by improving barrier function.

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• Reports

  • Plasma AR and abiraterone-resistant prostate cancer

    By Alessandro Romanel, Delila Gasi Tandefelt, Vincenza Conteduca, Anuradha Jayaram, Nicola Casiraghi, Daniel Wetterskog, Samanta Salvi, Dino Amadori, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Giorgia Gurioli, Valentina Casadio, Suzanne Carreira, Jane Goodall, Anna Wingate, Roberta Ferraldeschi, Nina Tunariu, Penny Flohr, Ugo De Giorgi, Johann S. de Bono, Francesca Demichelis, Gerhardt Attard

    Science Translational Medicine04 Nov 2015 : 312re10 Full AccessRestricted Access

    Androgen receptor mutations and amplifications in circulating tumor DNA provide clues to prostate cancer drug resistance.

    • Editor's Summary
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  • Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair

    By Firas L. Tarish, Niklas Schultz, Anna Tanoglidi, Hans Hamberg, Henry Letocha, Katalin Karaszi, Freddie C. Hamdy, Torvald Granfors, Thomas Helleday

    Science Translational Medicine04 Nov 2015 : 312re11 Full AccessRestricted Access

    Chemical castration decreases Ku70 expression impairing nonhomologous end joining DNA repair and improving the radiotherapy response of prostate cancer patients.

    • Editor's Summary
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• Editors' Choice

  • The hydrology of cerebrospinal fluid flow: Rivulets, fjords, and oceans

    By Christopher G. Janson

    Science Translational Medicine04 Nov 2015 : 312ec188 Full AccessRestricted Access

    Interstitial fluid flows to the mouse brain ventricles by convective bulk flow in a pathway complementary to that of the paravascular system.

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  • Hormonal response to energy restriction

    By Ian R. Lanza

    Science Translational Medicine04 Nov 2015 : 312ec189 Full AccessRestricted Access

    Humans and rodents differ in their hormonal responses to chronic caloric restriction.

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  • The skin-y on B cell subsets

    By Anne Marie Singh

    Science Translational Medicine04 Nov 2015 : 312ec190 Full AccessRestricted Access

    Atopic dermatitis is associated with system expansion of B cell subsets that correlate with disease severity.

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  • Personalized drug tablets with 3D printing

    By Andrew Z. Wang

    Science Translational Medicine04 Nov 2015 : 312ec191 Full AccessRestricted Access

    Drug tablets with release profiles tailored to individual patients can be formulated using 3D printing technique.

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