Contents
04 November 2015
Vol 7, Issue 312
Vol 7, Issue 312
Contents
Focus
- RSV vaccine: Beating the virus at its own game
Rational design hijacks RSV’s own transcriptional machinery to pave the way for an innovative live attenuated vaccine (Karron et al., this issue).
- Liquid biopsy: Clues on prostate cancer drug resistance
Analysis of tumor-derived cell-free DNA in blood yields insights into drug resistance in patients with castration-resistant prostate cancer (Romanel et al., this issue).
Research Articles
- A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children
A live attenuated vaccine candidate for RSV may decrease viral replication while enhancing immunogenicity in children.
- Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma
Histone chaperone FACT acts in a positive feedback loop with MYCN and is a therapeutic target in neuroblastoma.
- Sodium channel Nax is a regulator in epithelial sodium homeostasis
Blocking Nax expression improves scarring and atopic dermatitis–like symptoms by improving barrier function.
Reports
- Plasma AR and abiraterone-resistant prostate cancer
Androgen receptor mutations and amplifications in circulating tumor DNA provide clues to prostate cancer drug resistance.
- Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair
Chemical castration decreases Ku70 expression impairing nonhomologous end joining DNA repair and improving the radiotherapy response of prostate cancer patients.
Editors' Choice
- The hydrology of cerebrospinal fluid flow: Rivulets, fjords, and oceans
Interstitial fluid flows to the mouse brain ventricles by convective bulk flow in a pathway complementary to that of the paravascular system.
- Hormonal response to energy restriction
Humans and rodents differ in their hormonal responses to chronic caloric restriction.
- The skin-y on B cell subsets
Atopic dermatitis is associated with system expansion of B cell subsets that correlate with disease severity.
- Personalized drug tablets with 3D printing
Drug tablets with release profiles tailored to individual patients can be formulated using 3D printing technique.
About The Cover
ONLINE COVER Spilling Cancer's Secrets. This image shows a blood vessel adjacent to a tumor, with some of the tumor contents spilling out into the circulation. Just as a tumor contains a mixture of live and dead cells, the blood vessel contains live and dead tumor cells, as well as circulating DNA and RNA from the tumor. In this issue, Romanel et al. demonstrate that genetic changes associated with resistance to hormonal treatment can be detected in circulating tumor DNA from prostate cancer patients before they even start therapy, suggesting that analysis of circulating DNA may be able to guide the choice of treatment. A Focus by Schweizer and Antonarakis discusses the implications of this finding. [CREDIT: H. MCDONALD/SCIENCE TRANSLATIONAL MEDICINE]