Inflammation activation and resolution in human tendon disease

Stephanie G. Dakin; Fernando O. Martinez; Clarence Yapp; Graham Wells; Udo Oppermann; Benjamin J. F. Dean; Richard D. J. Smith; Kim Wheway; Bridget Watkins; Lucy Roche; Andrew J. Carr

doi:10.1126/scitranslmed.aac4269

Research ArticleTENDINOPATHY

Inflammation activation and resolution in human tendon disease

Stephanie G. Dakin¹,²,*,
Fernando O. Martinez¹,
Clarence Yapp³,
Graham Wells¹,
Udo Oppermann¹,³,
Benjamin J. F. Dean¹,²,
Richard D. J. Smith¹,²,
Kim Wheway¹,²,
Bridget Watkins¹,²,
Lucy Roche¹,² and
Andrew J. Carr¹,²

¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.
²NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.
³Structural Genomics Consortium, University of Oxford, Old Road Campus, Headington OX3 7DQ, UK.

↵*Corresponding author. E-mail: stephanie.dakin@ndorms.ox.ac.uk

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Science Translational Medicine 28 Oct 2015:
Vol. 7, Issue 311, pp. 311ra173
DOI: 10.1126/scitranslmed.aac4269

Stephanie G. Dakin

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

2NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.

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Fernando O. Martinez

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

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Clarence Yapp

3Structural Genomics Consortium, University of Oxford, Old Road Campus, Headington OX3 7DQ, UK.

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Graham Wells

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

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Udo Oppermann

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

3Structural Genomics Consortium, University of Oxford, Old Road Campus, Headington OX3 7DQ, UK.

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Benjamin J. F. Dean

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

2NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.

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Richard D. J. Smith

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

2NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.

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Kim Wheway

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

2NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.

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Bridget Watkins

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

2NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.

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Lucy Roche

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

2NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.

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Andrew J. Carr

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK.

2NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.

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Inflammation activation and resolution in human tendon disease

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