Research ArticleTENDINOPATHY

Inflammation activation and resolution in human tendon disease

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Science Translational Medicine  28 Oct 2015:
Vol. 7, Issue 311, pp. 311ra173
DOI: 10.1126/scitranslmed.aac4269

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Tending toward resolution

Inflammation activation and resolution pathways remain poorly defined in tendon disease. In new work, Dakin et al. investigate shoulder tendons from patients before and after surgery. Diseased tendons showed different inflammation gene and protein signatures in early-stage disease compared to advanced-stage disease. The researchers identified pathways implicated in the resolution of tendon pain after surgical treatment. Investigation of inflammation activation pathways in cultured stromal cells derived from human diseased tendons revealed that the stromal cells may have been primed for inflammation. The authors also identified a stable metabolite of aspirin that may be therapeutically beneficial for the resolution of tendon inflammation.

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