Research ArticleImmunotherapy

IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy

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Science Translational Medicine  28 Oct 2015:
Vol. 7, Issue 311, pp. 311ra170
DOI: 10.1126/scitranslmed.aac8155

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  • IL-2Rα mediated signalling defines the candidacy of IL-2

    IL-2Rα mediated signalling defines the candidacy of IL-2

    Interleukin-2 is a member of IL-2 family cytokine consisting of IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21, mediates differentiation of primary T cells into T-reg, T-cytotoxic and T-helper cells. It also has regulation on key immune functions like development of immunogenic memory in T cells, development of immune tolerance and clearance of cancer cells. The expression and signalling of IL-2 is tightly regulated in both negative and positive feedback loop. IL-2R, the receptor for IL-2 is expressed on leukocyte and lymphocytes cell surface is a complex of α, β and ϒ chains, where α-subunit has lower affinity for its ligand can increases upto 100 folds when complexed to β and ϒ chains (1). The commercial use of IL-2 as a chemotherapeutic drug is FDA approved in cancer therapy, but due to short life span and requirement of high therapeutic dose, it exhibits cytotoxic effects on host immune system. The cytokines IL-2 mediates its signalling cascade biased through IL2Rα constitutively expressed on T-reg cells that’s why IL-2 is the most essential for survival and expansion of T-reg cells. Su et al (2) investigated that administration of IL-2/m-Ab-IL-2 complex with increased half life demonstrates stronger and persistent effector T- cells function of transferred tumor reactive T cells in B6 model cancer mice. Authors have demonstrated that expression of IL-2Rα on donor cells outcompetes to the existing host cells f...

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    Competing Interests: None declared.

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