Contents
28 October 2015
Vol 7, Issue 311
Vol 7, Issue 311
Contents
Focus
- Preventing friendly fire in the war on microbes
Lung injury induced by Pseudomonas aeruginosa infection might be subverted by targeting a chromatin-remodeling protein (Zou et al., this issue).
Research Articles
- IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy
IL-2Rα sustains IL-2 immunotherapy response after cytokine withdrawal by recycling and cell surface reservoirs.
- Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia
Antagonism of Morf4l1 protein reduces lung cytotoxicity in a mouse model of pneumonia.
- Cell-selective arrhythmia ablation for photomodulation of heart rhythm
An injectable cardiomyocyte-targeted photosensitizer nanoparticle allows for specific in vivo arrhythmia ablation.
- Inflammation activation and resolution in human tendon disease
Resolution of inflammatory pathway gene expression signatures in diseased tendons correlates with reduced tendon pain.
- Identification of type 2 diabetes subgroups through topological analysis of patient similarity
Patient networks constructed from genotype data and electronic medical records pinpointed three type 2 diabetes subtypes.
Editors' Choice
- Neonatal analytics in the cloud
A cloud computing platform can perform analytical modeling of large-scale patient data from newborn babies.
- The curious case of the caramel apples
Apples, caramel, and a wooden stick synergistically make a hospitable growth environment for Listeria monocytogenes.
- A hop, skip, and a protein away
Exon skipping creates a truncated version of a protein missing in muscular dystrophy patients and ameliorates disease symptoms in flies and mice.
- Out with the old (myelin), in with the new
A pathway involved in clearing myelin debris offers new potential therapeutic targets for chronic demyelinating diseases.
- Lung cancer: A sanguine approach
Blood-based identification of resistance mechanisms can noninvasively select patients for treatment with third-generation EGFR inhibitors.
About The Cover
ONLINE COVER Art Imitates Life. This colorful graphic–a patient similarity network–may mark the beginning of a precision medicine approach to divide and conquer type 2 diabetes. As described by Li et al. in this issue, clinical data from electronic medical records were used to build the network, which identified the three completely segregated patient clusters shown in the cover art. The clusters correspond to type 2 diabetes patient subtypes 1 (762 patients), 2 (617 patients), and 3 (1096 patients), with red and blue representing an enrichment for female and male patients, respectively. Each cluster was associated with distinct comorbidities and genetic variant, which might shed light on disease pathophysiology and drive more precise diagnosis and therapy. [CREDIT: L. LI, J. DUDLEY/ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI]