28 October 2015
Vol 7, Issue 311

About The Cover

Cover image expansion

ONLINE COVER Art Imitates Life. This colorful graphic–a patient similarity network–may mark the beginning of a precision medicine approach to divide and conquer type 2 diabetes. As described by Li et al. in this issue, clinical data from electronic medical records were used to build the network, which identified the three completely segregated patient clusters shown in the cover art. The clusters correspond to type 2 diabetes patient subtypes 1 (762 patients), 2 (617 patients), and 3 (1096 patients), with red and blue representing an enrichment for female and male patients, respectively. Each cluster was associated with distinct comorbidities and genetic variant, which might shed light on disease pathophysiology and drive more precise diagnosis and therapy. [CREDIT: L. LI, J. DUDLEY/ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI]