21 October 2015
Vol 7, Issue 310

About The Cover

Cover image expansion

ONLINE COVER All in the Head. This image shows the head of a mouse with the brain tumor glioblastoma highlighted in color, using computational tomography combined with positron emission tomography (PET). Standard PET detects the uptake of glucose and cannot be used to image brain tumors because normal brain cells need as much glucose as cancer cells. Now, Witney et al. show that a different radiotracer, which takes advantage of metabolic abnormalities in the tumor, can clearly distinguish tumors from normal brain in mouse models. [CREDIT: TIMOTHY H. WITNEY, MICHELLE L. JAMES, AND SANJIV S. GAMBHIR/STANFORD UNIVERSITY SCHOOL OF MEDICINE]