Research ArticleAlzheimer’s Disease

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models

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Science Translational Medicine  14 Oct 2015:
Vol. 7, Issue 309, pp. 309ra164
DOI: 10.1126/scitranslmed.aab3492

Article Information

vol. 7 no. 309 309ra164

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 15, 2015
  • Accepted for publication September 24, 2015
  • .

Author Information

  1. Yunhong Huang1,2,
  2. Aneta Skwarek-Maruszewska1,2,
  3. Katrien Horré1,2,
  4. Elke Vandewyer1,2,
  5. Leen Wolfs1,2,
  6. An Snellinx1,2,
  7. Takashi Saito3,4,
  8. Enrico Radaelli1,2,
  9. Nikky Corthout1,2,
  10. Julien Colombelli5,
  11. Adrian C. Lo6,
  12. Leen Van Aerschot6,
  13. Zsuzsanna Callaerts-Vegh6,
  14. Daniah Trabzuni7,8,
  15. Koen Bossers9,
  16. Joost Verhaagen9,
  17. Mina Ryten7,
  18. Sebastian Munck1,2,
  19. Rudi D’Hooge6,
  20. Dick F. Swaab9,
  21. John Hardy7,
  22. Takaomi C. Saido3,
  23. Bart De Strooper1,2,* and
  24. Amantha Thathiah1,2,*
  1. 1VIB Center for the Biology of Disease, 3000 Leuven, Belgium.
  2. 2KU Leuven Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, 3000 Leuven, Belgium.
  3. 3Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, 351-0198 Saitama, Japan.
  4. 4Japan Science and Technology Agency, 332-0012 Saitama, Japan.
  5. 5Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
  6. 6Department of Psychology, Laboratory of Biological Psychology, University of Leuven, 3000 Leuven, Belgium.
  7. 7Departments of Molecular Neuroscience and Clinical Neuroscience, Reta Lila Weston Research Laboratories, Institute of Neurology, University College London, WC1N 3BG London, UK.
  8. 8Department of Genetics, King Faisal Specialist Hospital and Research Centre, 11211 Riyadh, Saudi Arabia.
  9. 9Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, Netherlands.
  1. *Corresponding author. E-mail: amantha.thathiah{at}cme.vib-kuleuven.be (A.T.); bart.destrooper{at}cme.vib-kuleuven.be (B.D.S.)

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