14 October 2015
Vol 7, Issue 309

About The Cover

Cover image expansion

ONLINE COVER Alzheimer's Disease in Plain Sight. The image is a color projection of a transgenic mouse brain rendered transparent and imaged with light sheet fluorescence microscopy. The transgenic mouse is a model of Alzheimer's disease, and the pathological hallmark of this disorder, amyloid plaques, are labeled in yellow (the cerebral vasculature is labeled in blue). Using several different Alzheimer's disease mouse models, including this transgenic mouse, Huang et al. have identified a new druggable target, G protein–coupled receptor 3, that when decreased results in reduced amyloid pathology. [CREDIT: J. COLOMBELLI/IRB BARCELONA]