Research ArticleCancer
TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL
- Ilan R. Kirsch1,*,
- Rei Watanabe2,*,
- John T. O’Malley2,
- David W. Williamson1,
- Laura-Louise Scott2,
- Christopher P. Elco3,
- Jessica E. Teague2,
- Ahmed Gehad2,
- Elizabeth L. Lowry2,
- Nicole R. LeBoeuf2,4,
- James G. Krueger5,
- Harlan S. Robins1,
- Thomas S. Kupper2,4,† and
- Rachael A. Clark2,4,†
- 1Adaptive Biotechnologies, Seattle, WA 98102, USA.
- 2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 3Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 4Dana-Farber/Brigham and Women’s Cancer Center, Boston, MA 02115, USA.
- 5Department of Dermatology, Rockefeller University, New York, NY 10065, USA.
- ↵†Corresponding author. E-mail: rclark1{at}partners.org (R.A.C.); tkupper{at}partners.org (T.S.K.)
↵* These authors contributed equally to this work and should be considered as co-first authors.
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Science Translational Medicine 07 Oct 2015:
Vol. 7, Issue 308, pp. 308ra158
DOI: 10.1126/scitranslmed.aaa9122
Vol. 7, Issue 308, pp. 308ra158
DOI: 10.1126/scitranslmed.aaa9122
Ilan R. Kirsch
1Adaptive Biotechnologies, Seattle, WA 98102, USA.
Rei Watanabe
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
John T. O’Malley
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
David W. Williamson
1Adaptive Biotechnologies, Seattle, WA 98102, USA.
Laura-Louise Scott
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Christopher P. Elco
3Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jessica E. Teague
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ahmed Gehad
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Elizabeth L. Lowry
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Nicole R. LeBoeuf
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
4Dana-Farber/Brigham and Women’s Cancer Center, Boston, MA 02115, USA.
James G. Krueger
5Department of Dermatology, Rockefeller University, New York, NY 10065, USA.
Harlan S. Robins
1Adaptive Biotechnologies, Seattle, WA 98102, USA.
Thomas S. Kupper
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
4Dana-Farber/Brigham and Women’s Cancer Center, Boston, MA 02115, USA.
Rachael A. Clark
2Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
4Dana-Farber/Brigham and Women’s Cancer Center, Boston, MA 02115, USA.
