Human IFNAR2 deficiency: Lessons for antiviral immunity

Christopher J. A. Duncan; Siti M. B. Mohamad; Dan F. Young; Andrew J. Skelton; T. Ronan Leahy; Diane C. Munday; Karina M. Butler; Sofia Morfopoulou; Julianne R. Brown; Mike Hubank; Jeff Connell; Patrick J. Gavin; Cathy McMahon; Eugene Dempsey; Niamh E. Lynch; Thomas S. Jacques; Manoj Valappil; Andrew J. Cant; Judith Breuer; Karin R. Engelhardt; Richard E. Randall; Sophie Hambleton

doi:10.1126/scitranslmed.aac4227

Research ArticleInfectious Disease

Human IFNAR2 deficiency: Lessons for antiviral immunity

Christopher J. A. Duncan¹,²,*,
Siti M. B. Mohamad¹,³,
Dan F. Young⁴,
Andrew J. Skelton⁵,
T. Ronan Leahy⁶,
Diane C. Munday⁴,
Karina M. Butler⁶,
Sofia Morfopoulou⁷,
Julianne R. Brown⁸,⁹,
Mike Hubank¹⁰,
Jeff Connell¹¹,
Patrick J. Gavin⁶,
Cathy McMahon¹²,
Eugene Dempsey¹³,
Niamh E. Lynch¹⁴,
Thomas S. Jacques¹⁵,
Manoj Valappil¹⁶,
Andrew J. Cant¹,¹⁷,
Judith Breuer⁷,⁸,
Karin R. Engelhardt¹,
Richard E. Randall⁴ and
Sophie Hambleton¹,¹⁷,*

¹Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.
²Department of Infectious Diseases and Tropical Medicine, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
³Advanced Medical and Dental Institute, Universiti Sains Malaysia, 11800 Penang, Malaysia.
⁴School of Biology, University of St. Andrews, St. Andrews KY16 9ST, UK.
⁵Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.
⁶Department of Pediatric Infectious Diseases and Immunology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.
⁷Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
⁸Virology Department, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust, London WC1N 3JH, UK.
⁹National Institutes of Health Research Biomedical Research Centre, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
¹⁰Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London WC1E 6BT, UK.
¹¹National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland.
¹²Department of Pediatric Intensive Care and Anaesthetics, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.
¹³INFANT Centre, Cork University Maternity Hospital, University College Cork, Ireland.
¹⁴Department of Pediatrics, Bon Secours Hospital, Cork, Ireland.
¹⁵Developmental Biology and Cancer Programme, University College London Institute of Child Health, London WC1N 1EH, UK.
¹⁶Public Health England, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
¹⁷Pediatric Immunology Service, Great North Children’s Hospital, Newcastle upon Tyne NE1 4LP, UK.

↵*Corresponding author. E-mail: christopher.duncan{at}ncl.ac.uk (C.J.A.D.); sophie.hambleton{at}ncl.ac.uk (S.H.)

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Science Translational Medicine 30 Sep 2015:
Vol. 7, Issue 307, pp. 307ra154
DOI: 10.1126/scitranslmed.aac4227

Christopher J. A. Duncan

1Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.

2Department of Infectious Diseases and Tropical Medicine, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.

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For correspondence: christopher.duncan@ncl.ac.uk sophie.hambleton@ncl.ac.uk

Siti M. B. Mohamad

1Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.

3Advanced Medical and Dental Institute, Universiti Sains Malaysia, 11800 Penang, Malaysia.

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Dan F. Young

4School of Biology, University of St. Andrews, St. Andrews KY16 9ST, UK.

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Andrew J. Skelton

5Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.

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T. Ronan Leahy

6Department of Pediatric Infectious Diseases and Immunology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

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Diane C. Munday

4School of Biology, University of St. Andrews, St. Andrews KY16 9ST, UK.

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Karina M. Butler

6Department of Pediatric Infectious Diseases and Immunology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

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Sofia Morfopoulou

7Division of Infection and Immunity, University College London, London WC1E 6BT, UK.

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Julianne R. Brown

8Virology Department, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust, London WC1N 3JH, UK.

9National Institutes of Health Research Biomedical Research Centre, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.

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Mike Hubank

10Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London WC1E 6BT, UK.

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Jeff Connell

11National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland.

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Patrick J. Gavin

6Department of Pediatric Infectious Diseases and Immunology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

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Cathy McMahon

12Department of Pediatric Intensive Care and Anaesthetics, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

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Eugene Dempsey

13INFANT Centre, Cork University Maternity Hospital, University College Cork, Ireland.

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Niamh E. Lynch

14Department of Pediatrics, Bon Secours Hospital, Cork, Ireland.

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Thomas S. Jacques

15Developmental Biology and Cancer Programme, University College London Institute of Child Health, London WC1N 1EH, UK.

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Manoj Valappil

16Public Health England, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.

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Andrew J. Cant

1Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.

17Pediatric Immunology Service, Great North Children’s Hospital, Newcastle upon Tyne NE1 4LP, UK.

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Judith Breuer

7Division of Infection and Immunity, University College London, London WC1E 6BT, UK.

8Virology Department, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust, London WC1N 3JH, UK.

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Karin R. Engelhardt

1Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.

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Richard E. Randall

4School of Biology, University of St. Andrews, St. Andrews KY16 9ST, UK.

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Sophie Hambleton

1Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.

17Pediatric Immunology Service, Great North Children’s Hospital, Newcastle upon Tyne NE1 4LP, UK.

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For correspondence: christopher.duncan@ncl.ac.uk sophie.hambleton@ncl.ac.uk

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