Research ArticleInfectious Disease

Human IFNAR2 deficiency: Lessons for antiviral immunity

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Science Translational Medicine  30 Sep 2015:
Vol. 7, Issue 307, pp. 307ra154
DOI: 10.1126/scitranslmed.aac4227

Article Information

vol. 7 no. 307 307ra154

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History: 
  • Received for publication April 24, 2015
  • Accepted for publication July 24, 2015

Author Information

  1. Christopher J. A. Duncan1,2,*,
  2. Siti M. B. Mohamad1,3,
  3. Dan F. Young4,
  4. Andrew J. Skelton5,
  5. T. Ronan Leahy6,
  6. Diane C. Munday4,
  7. Karina M. Butler6,
  8. Sofia Morfopoulou7,
  9. Julianne R. Brown8,9,
  10. Mike Hubank10,
  11. Jeff Connell11,
  12. Patrick J. Gavin6,
  13. Cathy McMahon12,
  14. Eugene Dempsey13,
  15. Niamh E. Lynch14,
  16. Thomas S. Jacques15,
  17. Manoj Valappil16,
  18. Andrew J. Cant1,17,
  19. Judith Breuer7,8,
  20. Karin R. Engelhardt1,
  21. Richard E. Randall4 and
  22. Sophie Hambleton1,17,*
  1. 1Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.
  2. 2Department of Infectious Diseases and Tropical Medicine, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
  3. 3Advanced Medical and Dental Institute, Universiti Sains Malaysia, 11800 Penang, Malaysia.
  4. 4School of Biology, University of St. Andrews, St. Andrews KY16 9ST, UK.
  5. 5Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.
  6. 6Department of Pediatric Infectious Diseases and Immunology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.
  7. 7Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  8. 8Virology Department, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust, London WC1N 3JH, UK.
  9. 9National Institutes of Health Research Biomedical Research Centre, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
  10. 10Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London WC1E 6BT, UK.
  11. 11National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland.
  12. 12Department of Pediatric Intensive Care and Anaesthetics, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.
  13. 13INFANT Centre, Cork University Maternity Hospital, University College Cork, Ireland.
  14. 14Department of Pediatrics, Bon Secours Hospital, Cork, Ireland.
  15. 15Developmental Biology and Cancer Programme, University College London Institute of Child Health, London WC1N 1EH, UK.
  16. 16Public Health England, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
  17. 17Pediatric Immunology Service, Great North Children’s Hospital, Newcastle upon Tyne NE1 4LP, UK.
  1. *Corresponding author. E-mail: christopher.duncan{at}ncl.ac.uk (C.J.A.D.); sophie.hambleton{at}ncl.ac.uk (S.H.)

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