Research ArticleAsthma

Early infancy microbial and metabolic alterations affect risk of childhood asthma

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Science Translational Medicine  30 Sep 2015:
Vol. 7, Issue 307, pp. 307ra152
DOI: 10.1126/scitranslmed.aab2271

Article Information

vol. 7 no. 307 307ra152

PubMed: 
Print ISSN: 
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History: 
  • Received for publication April 12, 2015
  • Accepted for publication August 7, 2015
  • .

Author Information

  1. Marie-Claire Arrieta1,2,*,
  2. Leah T. Stiemsma2,3,*,
  3. Pedro A. Dimitriu2,
  4. Lisa Thorson1,
  5. Shannon Russell1,2,
  6. Sophie Yurist-Doutsch1,2,
  7. Boris Kuzeljevic3,
  8. Matthew J. Gold4,
  9. Heidi M. Britton1,
  10. Diana L. Lefebvre5,
  11. Padmaja Subbarao6,7,
  12. Piush Mandhane8,9,
  13. Allan Becker10,
  14. Kelly M. McNagny4,
  15. Malcolm R. Sears5,
  16. Tobias Kollmann3,11,
  17. the CHILD Study Investigators,
  18. William W. Mohn2,
  19. Stuart E. Turvey3,11,,§ and
  20. B. Brett Finlay1,2,12,,§
  1. 1Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
  2. 2Department of Microbiology & Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  3. 3Child & Family Research Institute and BC Children’s Hospital, Vancouver, British Columbia V4Z 4H4, Canada.
  4. 4Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  5. 5Department of Medicine, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
  6. 6Department of Pediatrics, University of Toronto, Toronto, Ontario M5S 2J7, Canada.
  7. 7Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  8. 8Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
  9. 9School of Public Health, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
  10. 10Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
  11. 11Department of Pediatrics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
  12. 12Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
  1. §Corresponding author. E-mail: sturvey{at}cw.bc.ca (S.E.T.); bfinlay{at}mail.ubc.ca (B.B.F.)
    • * These authors contributed equally to this work.

    • CHILD Study Investigators are listed in the Supplementary Materials.

    • These authors contributed equally to this work.

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