23 September 2015
Vol 7, Issue 306

About The Cover

Cover image expansion

ONLINE COVER The Light Internal. Congenital or acquired tissue defects in internal organs would benefit from a minimally invasive sealant—as opposed to standard sutures that require surgery. Roche and colleagues engineered a catheter system that deploys a reflective balloon and adhesive patch to seal these hard-to-reach defects within the body, such as the heart septal wall, as depicted on the cover. The patch is coated with an adhesive that is cured by ultraviolet light, and the balloon helps to reflect and spread the light to ensure total coverage. The authors demonstrated the efficacy of this balloon catheter system in not only the heart, but also the abdominal wall and stomach of rats and pigs. [CREDIT: E. ROCHE, J. WEAVER/HARVARD UNIVERSITY]