Research ArticleVirology

Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection

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Science Translational Medicine  16 Sep 2015:
Vol. 7, Issue 305, pp. 305ra144
DOI: 10.1126/scitranslmed.aab3467

An animal model for the “Good Boy Virus”

Human pegivirus (HPgV, formerly called GB virus C) can protect HIV-infected individuals from developing AIDS, a phenomenon that has earned it the nickname of the “Good Boy Virus.” How HPgV imparts this protective effect remains a mystery, in part because no animal model of HPgV infection exists. Bailey and colleagues discovered viruses related to HPgV in wild baboons and showed that these viruses can infect laboratory macaque monkeys, providing unprecedented insights into the transmission, replication, and anatomical preference of HPgV with a view towards understanding HPgV-mediated protection from AIDS.

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