16 September 2015
Vol 7, Issue 305

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ONLINE COVER Pain-Free Pigs. The drug resiniferatoxin, an agonist of TRPV1 receptors, is a potent analgesic in a swine model of pain transmission, Brown et al.. Resiniferatoxin, delivered by computed-tomography guided injection to the dorsal root ganglia of swine, exerts its analgesic effect by killing off the nociceptive neurons expressing TRPV1 while preserving proprioceptive and somatosensory neurons that do not express this receptor. Treatment with resiniferatoxin rendered the pigs resistant to infrared laser heat stimuli that would normally induce a withdrawal response. Precise delivery of resiniferatoxin to sites of peripheral pain transmission may be a therapeutic approach for treating a variety of pain conditions in human patients. [CREDIT: MACDUFF EVERTON/CORBIS]