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Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

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Science Translational Medicine  09 Sep 2015:
Vol. 7, Issue 304, pp. 304ra142
DOI: 10.1126/scitranslmed.aaa3863

Article Information

vol. 7 no. 304 304ra142

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 27, 2014
  • Accepted for publication July 8, 2015
  • .

Author Information

  1. Naphak Modhiran1,*,
  2. Daniel Watterson1,2,*,
  3. David A. Muller1,3,
  4. Adele K. Panetta1,
  5. David P. Sester1,
  6. Lidong Liu1,,
  7. David A. Hume2,,
  8. Katryn J. Stacey1,2,§ and
  9. Paul R. Young1,2,§
  1. 1Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.
  2. 2Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
  3. 3Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland 4072, Australia.
  1. §Corresponding authors. E-mail: p.young{at}uq.edu.au (P.R.Y.); katryn.stacey{at}uq.edu.au (K.J.S.)
    • * These authors contributed equally to this work.

    • Present address: Division of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, P. R. China.

    • Present address: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

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