Research ArticleSepsis

Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

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Science Translational Medicine  02 Sep 2015:
Vol. 7, Issue 303, pp. 303ra140
DOI: 10.1126/scitranslmed.aab3459

Article Information

vol. 7 no. 303 303ra140

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 17, 2015
  • Accepted for publication July 23, 2015
  • .

Author Information

  1. Shaun Spence1,*,
  2. Michelle K. Greene2,*,
  3. François Fay2,3,
  4. Emily Hams4,
  5. Sean P. Saunders4,
  6. Umar Hamid1,
  7. Marianne Fitzgerald1,
  8. Jonathan Beck1,
  9. Baljinder K. Bains2,
  10. Peter Smyth2,
  11. Efrosyni Themistou5,
  12. Donna M. Small1,
  13. Daniela Schmid2,
  14. Cecilia M. O’Kane1,
  15. Denise C. Fitzgerald1,
  16. Sharif M. Abdelghany2,6,
  17. James A. Johnston1,7,
  18. Padraic G. Fallon4,8,
  19. James F. Burrows2,
  20. Daniel F. McAuley1,
  21. Adrien Kissenpfennig1 and
  22. Christopher J. Scott2,
  1. 1Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast BT9 7AE, UK.
  2. 2School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK.
  3. 3Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  4. 4Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
  5. 5School of Chemistry and Chemical Engineering, Queen’s University Belfast, Belfast BT9 5AG, UK.
  6. 6Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan.
  7. 7Inflammation Research, Amgen Inc., Thousand Oaks, CA 91320, USA.
  8. 8National Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin 12, Ireland.
  1. Corresponding author. E-mail: c.scott{at}qub.ac.uk
    • * These authors contributed equally to this work.

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