Research ArticleImmunotherapy

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

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Science Translational Medicine  02 Sep 2015:
Vol. 7, Issue 303, pp. 303ra139
DOI: 10.1126/scitranslmed.aac5415

Article Information

vol. 7 no. 303 303ra139

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 11, 2015
  • Accepted for publication June 29, 2015

Author Information

  1. David L. Porter1,*,
  2. Wei-Ting Hwang2,
  3. Noelle V. Frey1,
  4. Simon F. Lacey3,
  5. Pamela A. Shaw2,
  6. Alison W. Loren1,
  7. Adam Bagg3,
  8. Katherine T. Marcucci3,
  9. Angela Shen4,
  10. Vanessa Gonzalez3,
  11. David Ambrose3,
  12. Stephan A. Grupp5,
  13. Anne Chew3,
  14. Zhaohui Zheng3,
  15. Michael C. Milone3,
  16. Bruce L. Levine3,
  17. Jan J. Melenhorst3 and
  18. Carl H. June3,*
  1. 1Division of Hematology/Oncology, Department of Medicine, and Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  2. 2Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  3. 3Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  4. 4Novartis Pharmaceutical Corporation, One Health Plaza, East Hanover, NJ 07936, USA.
  5. 5Division of Oncology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  1. *Corresponding author. E-mail: david.porter{at}uphs.upenn.edu (D.L.P.); cjune{at}exchange.upenn.edu (C.H.J.)

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