A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

Laura R. Saunders; Alexander J. Bankovich; Wade C. Anderson; Monette A. Aujay; Sheila Bheddah; KristenAnn Black; Radhika Desai; Paul A. Escarpe; Johannes Hampl; Amy Laysang; David Liu; Javier Lopez-Molina; Milly Milton; Albert Park; Marybeth A. Pysz; Hui Shao; Brian Slingerland; Michael Torgov; Samuel A. Williams; Orit Foord; Philip Howard; Jacek Jassem; Andrzej Badzio; Piotr Czapiewski; David H. Harpole; Afshin Dowlati; Pierre P. Massion; William D. Travis; M. Catherine Pietanza; J. T. Poirier; Charles M. Rudin; Robert A. Stull; Scott J. Dylla

doi:10.1126/scitranslmed.aac9459

Research ArticleCancer

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

Laura R. Saunders¹,
Alexander J. Bankovich¹,
Wade C. Anderson¹,
Monette A. Aujay¹,
Sheila Bheddah¹,
KristenAnn Black¹,
Radhika Desai¹,
Paul A. Escarpe¹,
Johannes Hampl¹,
Amy Laysang¹,
David Liu¹,
Javier Lopez-Molina¹,
Milly Milton¹,
Albert Park¹,
Marybeth A. Pysz¹,
Hui Shao¹,
Brian Slingerland¹,
Michael Torgov¹,*,
Samuel A. Williams¹,
Orit Foord¹,
Philip Howard²,
Jacek Jassem³,
Andrzej Badzio³,
Piotr Czapiewski³,
David H. Harpole⁴,
Afshin Dowlati⁵,
Pierre P. Massion⁶,
William D. Travis⁷,
M. Catherine Pietanza⁷,⁸,
J. T. Poirier⁷,⁸,
Charles M. Rudin⁷,
Robert A. Stull¹ and
Scott J. Dylla¹,†

¹Stemcentrx Inc., South San Francisco, CA 94080, USA.
²Spirogen (a member of the AstraZeneca Group), London W2 6BD, UK.
³Medical University of Gdańsk, Gdańsk 82-300, Poland.
⁴Duke University Medical Cancer, Durham, NC 27710, USA.
⁵Case Western Reserve University and University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
⁶Thoracic Program, Vanderbilt-Ingram Cancer Center, Tennessee Valley Healthcare Systems, Nashville Campus, Nashville, TN 37232, USA.
⁷Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
⁸Weill Cornell Medical College, New York, NY 10065, USA.

↵†Corresponding author. E-mail: scott.dylla{at}stemcentrx.com

↵* Present address: ImaginAb Inc., Inglewood, CA 90301, USA.

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Science Translational Medicine 26 Aug 2015:
Vol. 7, Issue 302, pp. 302ra136
DOI: 10.1126/scitranslmed.aac9459

Laura R. Saunders

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Alexander J. Bankovich

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Wade C. Anderson

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Monette A. Aujay

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Sheila Bheddah

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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KristenAnn Black

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Radhika Desai

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Paul A. Escarpe

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Johannes Hampl

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Amy Laysang

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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David Liu

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Javier Lopez-Molina

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Milly Milton

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Albert Park

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Marybeth A. Pysz

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Hui Shao

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Brian Slingerland

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Michael Torgov

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Samuel A. Williams

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Orit Foord

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Philip Howard

2Spirogen (a member of the AstraZeneca Group), London W2 6BD, UK.

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Jacek Jassem

3Medical University of Gdańsk, Gdańsk 82-300, Poland.

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Andrzej Badzio

3Medical University of Gdańsk, Gdańsk 82-300, Poland.

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Piotr Czapiewski

3Medical University of Gdańsk, Gdańsk 82-300, Poland.

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David H. Harpole

4Duke University Medical Cancer, Durham, NC 27710, USA.

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Afshin Dowlati

5Case Western Reserve University and University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.

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Pierre P. Massion

6Thoracic Program, Vanderbilt-Ingram Cancer Center, Tennessee Valley Healthcare Systems, Nashville Campus, Nashville, TN 37232, USA.

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William D. Travis

7Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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M. Catherine Pietanza

7Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

8Weill Cornell Medical College, New York, NY 10065, USA.

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J. T. Poirier

7Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

8Weill Cornell Medical College, New York, NY 10065, USA.

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Charles M. Rudin

7Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Robert A. Stull

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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Scott J. Dylla

1Stemcentrx Inc., South San Francisco, CA 94080, USA.

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For correspondence: scott.dylla@stemcentrx.com

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A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

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