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A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

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Science Translational Medicine  26 Aug 2015:
Vol. 7, Issue 302, pp. 302ra136
DOI: 10.1126/scitranslmed.aac9459

Article Information

vol. 7 no. 302 302ra136

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 2, 2015
  • Accepted for publication August 5, 2015
  • .

Author Information

  1. Laura R. Saunders1,
  2. Alexander J. Bankovich1,
  3. Wade C. Anderson1,
  4. Monette A. Aujay1,
  5. Sheila Bheddah1,
  6. KristenAnn Black1,
  7. Radhika Desai1,
  8. Paul A. Escarpe1,
  9. Johannes Hampl1,
  10. Amy Laysang1,
  11. David Liu1,
  12. Javier Lopez-Molina1,
  13. Milly Milton1,
  14. Albert Park1,
  15. Marybeth A. Pysz1,
  16. Hui Shao1,
  17. Brian Slingerland1,
  18. Michael Torgov1,*,
  19. Samuel A. Williams1,
  20. Orit Foord1,
  21. Philip Howard2,
  22. Jacek Jassem3,
  23. Andrzej Badzio3,
  24. Piotr Czapiewski3,
  25. David H. Harpole4,
  26. Afshin Dowlati5,
  27. Pierre P. Massion6,
  28. William D. Travis7,
  29. M. Catherine Pietanza7,8,
  30. J. T. Poirier7,8,
  31. Charles M. Rudin7,
  32. Robert A. Stull1 and
  33. Scott J. Dylla1,
  1. 1Stemcentrx Inc., South San Francisco, CA 94080, USA.
  2. 2Spirogen (a member of the AstraZeneca Group), London W2 6BD, UK.
  3. 3Medical University of Gdańsk, Gdańsk 82-300, Poland.
  4. 4Duke University Medical Cancer, Durham, NC 27710, USA.
  5. 5Case Western Reserve University and University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
  6. 6Thoracic Program, Vanderbilt-Ingram Cancer Center, Tennessee Valley Healthcare Systems, Nashville Campus, Nashville, TN 37232, USA.
  7. 7Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  8. 8Weill Cornell Medical College, New York, NY 10065, USA.
  1. Corresponding author. E-mail: scott.dylla{at}stemcentrx.com
  • * Present address: ImaginAb Inc., Inglewood, CA 90301, USA.

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