Research ArticleSpinal Cord Injury
Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates
- Lucia Friedli1,
- Ephron S. Rosenzweig2,
- Quentin Barraud1,
- Martin Schubert3,
- Nadia Dominici1,4,
- Lea Awai3,
- Jessica L. Nielson5,
- Pavel Musienko1,6,
- Yvette Nout-Lomas7,
- Hui Zhong8,
- Sharon Zdunowski8,
- Roland R. Roy8,
- Sarah C. Strand9,
- Rubia van den Brand1,
- Leif A. Havton10,
- Michael S. Beattie11,
- Jacqueline C. Bresnahan11,
- Erwan Bézard12,13,
- Jocelyne Bloch14,
- V. Reggie Edgerton8,
- Adam R. Ferguson5,
- Armin Curt3,*,
- Mark H. Tuszynski2,15 and
- Grégoire Courtine1,14,†
- 1Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
- 2Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093–0662, USA.
- 3Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
- 4MOVE Research Institute Amsterdam, Faculty of Human Movement Sciences, VU University Amsterdam, 1081 BT Amsterdam, Netherlands.
- 5Department of Neurosurgery, University of California, San Francisco (UCSF), San Francisco, CA 94122, USA.
- 6Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg 199034, Russia.
- 7College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80521, USA.
- 8Department of Integrative Biology and Physiology and Brain Research Center, University of California, Los Angeles (UCLA), Los Angeles, CA 900095–7246, USA.
- 9California National Primate Research Center, University of California, Davis, Davis, CA 95616–8542, USA.
- 10Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095–1769, USA.
- 11Brain and Spinal Injury Center, UCSF, San Francisco, CA 94110, USA.
- 12Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
- 13CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
- 14Clinical Neuroscience, University Hospital of Vaud (CHUV), 1011 Lausanne, Switzerland.
- 15Veterans Administration Medical Center, San Diego, CA 92161, USA.
- ↵†Corresponding author. E-mail: gregoire.courtine{at}epfl.ch
↵* Head of the European Multicenter Study about Spinal Cord Injury study group.
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Science Translational Medicine 26 Aug 2015:
Vol. 7, Issue 302, pp. 302ra134
DOI: 10.1126/scitranslmed.aac5811
Vol. 7, Issue 302, pp. 302ra134
DOI: 10.1126/scitranslmed.aac5811
Lucia Friedli
1Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
Ephron S. Rosenzweig
2Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093–0662, USA.
Quentin Barraud
1Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
Martin Schubert
3Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Nadia Dominici
1Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
4MOVE Research Institute Amsterdam, Faculty of Human Movement Sciences, VU University Amsterdam, 1081 BT Amsterdam, Netherlands.
Lea Awai
3Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Jessica L. Nielson
5Department of Neurosurgery, University of California, San Francisco (UCSF), San Francisco, CA 94122, USA.
Pavel Musienko
1Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
6Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg 199034, Russia.
Yvette Nout-Lomas
7College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80521, USA.
Hui Zhong
8Department of Integrative Biology and Physiology and Brain Research Center, University of California, Los Angeles (UCLA), Los Angeles, CA 900095–7246, USA.
Sharon Zdunowski
8Department of Integrative Biology and Physiology and Brain Research Center, University of California, Los Angeles (UCLA), Los Angeles, CA 900095–7246, USA.
Roland R. Roy
8Department of Integrative Biology and Physiology and Brain Research Center, University of California, Los Angeles (UCLA), Los Angeles, CA 900095–7246, USA.
Sarah C. Strand
9California National Primate Research Center, University of California, Davis, Davis, CA 95616–8542, USA.
Rubia van den Brand
1Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
Leif A. Havton
10Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095–1769, USA.
Michael S. Beattie
11Brain and Spinal Injury Center, UCSF, San Francisco, CA 94110, USA.
Jacqueline C. Bresnahan
11Brain and Spinal Injury Center, UCSF, San Francisco, CA 94110, USA.
Erwan Bézard
12Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
13CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
Jocelyne Bloch
14Clinical Neuroscience, University Hospital of Vaud (CHUV), 1011 Lausanne, Switzerland.
V. Reggie Edgerton
8Department of Integrative Biology and Physiology and Brain Research Center, University of California, Los Angeles (UCLA), Los Angeles, CA 900095–7246, USA.
Adam R. Ferguson
5Department of Neurosurgery, University of California, San Francisco (UCSF), San Francisco, CA 94122, USA.
Armin Curt
3Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Mark H. Tuszynski
2Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093–0662, USA.
15Veterans Administration Medical Center, San Diego, CA 92161, USA.
Grégoire Courtine
1Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
14Clinical Neuroscience, University Hospital of Vaud (CHUV), 1011 Lausanne, Switzerland.