Research ArticleAsthma
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
- David F. Choy1,*,
- Kevin M. Hart2,*,
- Lee A. Borthwick3,
- Aarti Shikotra4,
- Deepti R. Nagarkar1,
- Salman Siddiqui4,
- Guiquan Jia1,
- Chandra M. Ohri4,
- Emma Doran1,5,
- Kevin M. Vannella2,
- Claire A. Butler5,
- Beverley Hargadon4,
- Joshua C. Sciurba2,
- Richard L. Gieseck2,
- Robert W. Thompson2,
- Sandra White2,
- Alexander R. Abbas1,
- Janet Jackman1,
- Lawren C. Wu1,
- Jackson G. Egen1,
- Liam G. Heaney5,
- Thirumalai R. Ramalingam2,
- Joseph R. Arron1,†,‡,
- Thomas A. Wynn2,† and
- Peter Bradding4,†
- 1Genentech Inc., South San Francisco, CA 94080, USA.
- 2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 3Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
- 4Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
- 5Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.
- ↵‡Corresponding author. E-mail: arron.joseph{at}gene.com
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Science Translational Medicine 19 Aug 2015:
Vol. 7, Issue 301, pp. 301ra129
DOI: 10.1126/scitranslmed.aab3142
Vol. 7, Issue 301, pp. 301ra129
DOI: 10.1126/scitranslmed.aab3142
David F. Choy
1Genentech Inc., South San Francisco, CA 94080, USA.
Kevin M. Hart
2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Lee A. Borthwick
3Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Aarti Shikotra
4Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
Deepti R. Nagarkar
1Genentech Inc., South San Francisco, CA 94080, USA.
Salman Siddiqui
4Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
Guiquan Jia
1Genentech Inc., South San Francisco, CA 94080, USA.
Chandra M. Ohri
4Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
Emma Doran
1Genentech Inc., South San Francisco, CA 94080, USA.
5Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.
Kevin M. Vannella
2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Claire A. Butler
5Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.
Beverley Hargadon
4Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
Joshua C. Sciurba
2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Richard L. Gieseck
2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Robert W. Thompson
2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sandra White
2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Alexander R. Abbas
1Genentech Inc., South San Francisco, CA 94080, USA.
Janet Jackman
1Genentech Inc., South San Francisco, CA 94080, USA.
Lawren C. Wu
1Genentech Inc., South San Francisco, CA 94080, USA.
Jackson G. Egen
1Genentech Inc., South San Francisco, CA 94080, USA.
Liam G. Heaney
5Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.
Thirumalai R. Ramalingam
2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Joseph R. Arron
1Genentech Inc., South San Francisco, CA 94080, USA.
Thomas A. Wynn
2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Peter Bradding
4Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
