Research ArticleAsthma
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
- David F. Choy1,*,
- Kevin M. Hart2,*,
- Lee A. Borthwick3,
- Aarti Shikotra4,
- Deepti R. Nagarkar1,
- Salman Siddiqui4,
- Guiquan Jia1,
- Chandra M. Ohri4,
- Emma Doran1,5,
- Kevin M. Vannella2,
- Claire A. Butler5,
- Beverley Hargadon4,
- Joshua C. Sciurba2,
- Richard L. Gieseck2,
- Robert W. Thompson2,
- Sandra White2,
- Alexander R. Abbas1,
- Janet Jackman1,
- Lawren C. Wu1,
- Jackson G. Egen1,
- Liam G. Heaney5,
- Thirumalai R. Ramalingam2,
- Joseph R. Arron1,†,‡,
- Thomas A. Wynn2,† and
- Peter Bradding4,†
- 1Genentech Inc., South San Francisco, CA 94080, USA.
- 2Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 3Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
- 4Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
- 5Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.
- ↵‡Corresponding author. E-mail: arron.joseph{at}gene.com
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Science Translational Medicine 19 Aug 2015:
Vol. 7, Issue 301, pp. 301ra129
DOI: 10.1126/scitranslmed.aab3142
Vol. 7, Issue 301, pp. 301ra129
DOI: 10.1126/scitranslmed.aab3142
David F. Choy
Genentech Inc., South San Francisco, CA 94080, USA.
Kevin M. Hart
Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Lee A. Borthwick
Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Aarti Shikotra
Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
Deepti R. Nagarkar
Genentech Inc., South San Francisco, CA 94080, USA.
Salman Siddiqui
Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
Guiquan Jia
Genentech Inc., South San Francisco, CA 94080, USA.
Chandra M. Ohri
Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
Emma Doran
Genentech Inc., South San Francisco, CA 94080, USA.
Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.
Kevin M. Vannella
Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Claire A. Butler
Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.
Beverley Hargadon
Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
Joshua C. Sciurba
Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Richard L. Gieseck
Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Robert W. Thompson
Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sandra White
Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Alexander R. Abbas
Genentech Inc., South San Francisco, CA 94080, USA.
Janet Jackman
Genentech Inc., South San Francisco, CA 94080, USA.
Lawren C. Wu
Genentech Inc., South San Francisco, CA 94080, USA.
Jackson G. Egen
Genentech Inc., South San Francisco, CA 94080, USA.
Liam G. Heaney
Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.
Thirumalai R. Ramalingam
Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Joseph R. Arron
Genentech Inc., South San Francisco, CA 94080, USA.
Thomas A. Wynn
Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Peter Bradding
Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.
