19 August 2015
Vol 7, Issue 301
  • Contents

    • Focus

    • Research Articles

      • TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma

        Concurrent blockade of IL-13 and IL-17A may improve control of asthma.

      • Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

        Obesity leads to fibrotic remodeling of mammary adipose tissue, and the resulting increase in interstitial extracellular matrix stiffness promotes breast tumor malignancy.

      • A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

        A consensus MERS spike protein synthetic DNA vaccine can induce protective responses against viral challenge.

    • Editors' Choice

      • Bile acids go up to BAT

        Bile acids activate brown adipose tissue in humans.

      • Unearthing archival tumor RNA

        New method for sequencing poor-quality RNA–derived formalin-fixed paraffin-embedded tissue should facilitate studies of tumor RNA.

      • Contagious biomaterials

        Surface-engineered biomaterials and cells mimic the tolerance-promoting properties of regulatory T cells.

About The Cover

Cover image expansion

ONLINE COVER Stiff Penalty for Obesity. Although known to be a major risk factor for breast cancer, how obesity drives disease is unclear. Seo et al. reveal that mechanical changes in the mammary environment—caused by obesity—may be the cancer culprit. The authors found that obese mice and humans had stiffer mammary extracellular matrices than their lean counterparts. In mice, myofibroblasts (spiky cell on cover) in fat tissue produced a stiffer matrix (in green) than usual, which stimulated premalignant cells to transform into cancerous ones. Caloric restriction in the mice decreased fibrosis, suggesting that a healthy diet could help reduce cancer risk. A related Focus is by Arendt and Kuperwasser. [CREDIT: H. MCDONALD/SCIENCE TRANSLATIONAL MEDICINE]