Contents
12 August 2015
Vol 7, Issue 300
Vol 7, Issue 300
Contents
Perspective
- Precision medicine: Beyond the inflection point
The convergence of biomedical, engineering, and health sciences has set the stage for a life-altering leap toward individualized health care.
Research Articles
- Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge
Animals exposed to attenuated SIV in utero showed reduced viral replication and altered immune responses after pathogenic challenge postnatally.
- Chimpanzee adenovirus– and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults
The RSV vaccine candidates PanAd3-RSV and MVA-RSV were safe and immunogenic in healthy adults.
- Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections
A vectored human RSV vaccine protects young seronegative calves.
- An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease
A hydrogel binds to inflamed tissues, delivering therapeutics locally and reducing systemic drug exposure in mouse models of inflammatory bowel disease.
Editors' Choice
- Unraveling the role of immune accessory molecules
B7-H3 protects against prostate tumors by modulating regulatory T cells in the tumor microenvironment.
- The curious case of intracranial lymphatics
Previously elusive intracranial lymphatic vessels and their functions have been mapped in transgenic mice by using lymphatic cell-specific reporters.
- Bed rest, then rehab
Older adults are more susceptible to muscle loss during bed rest, but exercise effectively reverses these detrimental effects.
- What’s bugging your gut?
Regulatory T cells promote tolerance to gut microbiota through MyD88 signaling.
- Shutting down the messenger: Antisense treatment for hypertriglyceridemia
Antisense therapy against the apolipoprotein C-III messenger RNA lowers triglyceride concentrations in patients with hypertriglyceridemia.
About The Cover
ONLINE COVER Moving Forward with an RSV Vaccine. Calves are natural hosts for bovine respiratory syncytial virus (RSV) infection. In people, RSV causes a severe lower respiratory tract disease that affects both children and the elderly. A pair of papers by Taylor et al. and Green et al. translate a prime-boost vaccine strategy for human RSV first into calves and then into humans in a phase 1 clinical trial. [CREDIT: TREASUREPHOTO/THINKSTOCK]