Research ArticleSepsis

A targeted real-time early warning score (TREWScore) for septic shock

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Science Translational Medicine  05 Aug 2015:
Vol. 7, Issue 299, pp. 299ra122
DOI: 10.1126/scitranslmed.aab3719

Evening the score against sepsis

Sepsis is a major cause of death, which remains difficult to treat despite modern antibiotics. Early aggressive treatment of this disease improves patient mortality, but the tools currently available in the clinic do not predict who will develop sepsis and its late manifestation, septic shock, until the patients are already in advanced stages of the disease. Henry et al. used readily available data from patient monitors and medical records to develop TREWScore, a targeted real-time early warning score that predicts in advance which patients are at risk for septic shock. With a median lead time of over 24 hours, this scoring algorithm may allow clinicians enough time to intervene before the patients suffer the most damaging effects of sepsis.

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