Research ArticleHIV

Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection

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Science Translational Medicine  29 Jul 2015:
Vol. 7, Issue 298, pp. 298ra120
DOI: 10.1126/scitranslmed.aab3964

How antibodies mature

Antibodies are stalwart protectors against infection, but even antibodies need a little help to do their jobs. T follicular helper (TFH) cells can guide B cells to produce antibodies with improved specificity to a particular pathogen through a process called affinity maturation. Now, Yamamoto et al. report that in nonhuman primates, the frequency and quality of TFH cells were associated with the development of broadly neutralizing antibodies that may be protective against SHIV. These findings suggest that HIV vaccines that incorporate TFH cell stimulation may boost broadly neutralizing antibody production.

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