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Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

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Science Translational Medicine  29 Jul 2015:
Vol. 7, Issue 298, pp. 298ra117
DOI: 10.1126/scitranslmed.aaa7619

Article Information

vol. 7 no. 298 298ra117

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 25, 2015
  • Accepted for publication June 1, 2015

Author Information

  1. Hong Cai1,*,
  2. Edwina Scott1,*,
  3. Abeer Kholghi1,
  4. Catherine Andreadi1,
  5. Alessandro Rufini1,
  6. Ankur Karmokar1,
  7. Robert G. Britton1,
  8. Emma Horner-Glister1,
  9. Peter Greaves1,
  10. Dhafer Jawad1,
  11. Mark James1,
  12. Lynne Howells1,
  13. Ted Ognibene2,
  14. Michael Malfatti2,
  15. Christopher Goldring3,
  16. Neil Kitteringham3,
  17. Joanne Walsh3,
  18. Maria Viskaduraki4,
  19. Kevin West5,
  20. Andrew Miller5,
  21. David Hemingway5,
  22. William P. Steward1,
  23. Andreas J. Gescher1 and
  24. Karen Brown1,
  1. 1Cancer Chemoprevention Group, Department of Cancer Studies, University of Leicester, Leicester LE2 7LX, UK.
  2. 2Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA.
  3. 3MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, UK.
  4. 4Bioinformatics and Biostatistics Support Hub, University of Leicester, Maurice Shock Building, Leicester LE1 9HN, UK.
  5. 5University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
  1. Corresponding author. E-mail: kb20{at}le.ac.uk
    • * These authors contributed equally to this work.

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