Research ArticleDRUG RESISTANCE
Fitness cost of antibiotic susceptibility during bacterial infection
- Damien Roux1,2,3,*,
- Olga Danilchanka4,*,
- Thomas Guillard1,5,†,
- Vincent Cattoir4,6,†,
- Hugues Aschard7,
- Yang Fu4,
- Francois Angoulvant8,
- Jonathan Messika2,
- Jean-Damien Ricard2,
- John J. Mekalanos4,
- Stephen Lory4,
- Gerald B. Pier1,‡ and
- David Skurnik1,‡
- 1Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 2INSERM, IAME, UMR 1137, F-75018 Paris, France.
- 3Université Paris Diderot, Sorbonne Paris Cité, F-75018 Paris, France.
- 4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
- 5EA 4687, Faculté de Médecine, Université de Reims Champagne-Ardenne, 51092 Reims, France.
- 6EA 4655, Faculté de Médecine, Université de Caen Basse-Normandie, 14033 Caen, France.
- 7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
- 8Hôpitaux de Paris (AP-HP), Pédiatrique Emergency Département, Hôpital Necker-Enfants Malades and Université Paris Descartes, 75015 Paris, France.
- ↵‡Corresponding author. E-mail: gpier{at}bwh.harvard.edu (G.B.P.); dskurnik{at}rics.bwh.harvard.edu (D.S.)
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Science Translational Medicine 22 Jul 2015:
Vol. 7, Issue 297, pp. 297ra114
DOI: 10.1126/scitranslmed.aab1621
Vol. 7, Issue 297, pp. 297ra114
DOI: 10.1126/scitranslmed.aab1621
Damien Roux
1Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
2INSERM, IAME, UMR 1137, F-75018 Paris, France.
3Université Paris Diderot, Sorbonne Paris Cité, F-75018 Paris, France.
Olga Danilchanka
4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Thomas Guillard
1Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
5EA 4687, Faculté de Médecine, Université de Reims Champagne-Ardenne, 51092 Reims, France.
Vincent Cattoir
4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
6EA 4655, Faculté de Médecine, Université de Caen Basse-Normandie, 14033 Caen, France.
Hugues Aschard
7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Yang Fu
4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Francois Angoulvant
8Hôpitaux de Paris (AP-HP), Pédiatrique Emergency Département, Hôpital Necker-Enfants Malades and Université Paris Descartes, 75015 Paris, France.
Jonathan Messika
2INSERM, IAME, UMR 1137, F-75018 Paris, France.
Jean-Damien Ricard
2INSERM, IAME, UMR 1137, F-75018 Paris, France.
John J. Mekalanos
4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Stephen Lory
4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Gerald B. Pier
1Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
David Skurnik
1Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
