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The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

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Science Translational Medicine  22 Jul 2015:
Vol. 7, Issue 297, pp. 297ra113
DOI: 10.1126/scitranslmed.aab1290

Article Information

vol. 7 no. 297 297ra113

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 12, 2014
  • Accepted for publication June 26, 2015
  • .

Author Information

  1. Laszlo Prokai1,2,*,
  2. Vien Nguyen1,
  3. Szabolcs Szarka1,,
  4. Puja Garg1,3,,
  5. Gauri Sabnis4,
  6. Heather A. Bimonte-Nelson5,6,
  7. Katie J. McLaughlin5,§,
  8. Joshua S. Talboom5,6,
  9. Cheryl D. Conrad5,
  10. Paul J. Shughrue7,,
  11. Todd D. Gould4,8,9,
  12. Angela Brodie4,
  13. Istvan Merchenthaler9,10,
  14. Peter Koulen3 and
  15. Katalin Prokai-Tatrai1,2
  1. 1Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  2. 2AgyPharma LLC, Mansfield, TX 76063, USA.
  3. 3Vision Research Center and Departments of Ophthalmology and Basic Medical Science, University of Missouri–Kansas City, School of Medicine, Kansas City, MO 64108, USA.
  4. 4Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  5. 5Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
  6. 6Arizona Alzheimer’s Consortium, Tempe, AZ 85014, USA.
  7. 7Department of Pharmacology, Elan Pharmaceuticals Inc., South San Francisco, CA 94080, USA.
  8. 8Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  9. 9Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  10. 10Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  1. *Corresponding author. E-mail: laszlo.prokai{at}unthsc.edu
    • Present address: LGC, Fordham, Cambridgeshire CB7 5WW, UK.

    • Present address: University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

    • § Present address: Eli Lilly and Company, Indianapolis, IN 46285, USA.

    • Present address: Prothena Biosciences, South San Francisco, CA 94080, USA.

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