Research ArticleHIV
HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition
- Heather A. Prentice1,2,*,
- Georgia D. Tomaras3,
- Daniel E. Geraghty4,
- Richard Apps5,
- Youyi Fong6,
- Philip K. Ehrenberg1,
- Morgane Rolland1,2,
- Gustavo H. Kijak1,2,
- Shelly J. Krebs1,2,
- Wyatt Nelson4,
- Allan DeCamp6,
- Xiaoying Shen3,
- Nicole L. Yates3,
- Susan Zolla-Pazner7,
- Sorachai Nitayaphan8,
- Supachai Rerks-Ngarm9,
- Jaranit Kaewkungwal10,
- Punnee Pitisuttithum11,
- Guido Ferrari3,
- M. Juliana McElrath6,
- David C. Montefiori3,
- Robert T. Bailer12,
- Richard A. Koup12,
- Robert J. O’Connell8,
- Merlin L. Robb1,2,
- Nelson L. Michael1,
- Peter B. Gilbert6,
- Jerome H. Kim1 and
- Rasmi Thomas1,2,†
- 1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
- 2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA.
- 3Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
- 4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
- 5Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
- 6Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
- 7Veterans Affairs New York Harbor Healthcare System and the Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
- 8Department of Retrovirology, U.S. Army Medical Component, Armed Forces Research Institute Medical Sciences, Bangkok 10400, Thailand.
- 9Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand.
- 10Center of Excellence for Biomedical and Public Health Informatics (BIOPHICS), Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
- 11Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
- 12Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- ↵†Corresponding author. E-mail: rthomas{at}hivresearch.org
↵* Present address: Inova Fairfax Medical Campus, 3300 Gallows Road, Falls Church, VA 22042, USA.
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Science Translational Medicine 15 Jul 2015:
Vol. 7, Issue 296, pp. 296ra112
DOI: 10.1126/scitranslmed.aab4005
Vol. 7, Issue 296, pp. 296ra112
DOI: 10.1126/scitranslmed.aab4005
Heather A. Prentice
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA.
Georgia D. Tomaras
3Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Daniel E. Geraghty
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Richard Apps
5Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Youyi Fong
6Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Philip K. Ehrenberg
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Morgane Rolland
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA.
Gustavo H. Kijak
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA.
Shelly J. Krebs
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA.
Wyatt Nelson
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Allan DeCamp
6Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Xiaoying Shen
3Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Nicole L. Yates
3Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Susan Zolla-Pazner
7Veterans Affairs New York Harbor Healthcare System and the Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Sorachai Nitayaphan
8Department of Retrovirology, U.S. Army Medical Component, Armed Forces Research Institute Medical Sciences, Bangkok 10400, Thailand.
Supachai Rerks-Ngarm
9Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand.
Jaranit Kaewkungwal
10Center of Excellence for Biomedical and Public Health Informatics (BIOPHICS), Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Punnee Pitisuttithum
11Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Guido Ferrari
3Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
M. Juliana McElrath
6Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
David C. Montefiori
3Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Robert T. Bailer
12Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Richard A. Koup
12Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Robert J. O’Connell
8Department of Retrovirology, U.S. Army Medical Component, Armed Forces Research Institute Medical Sciences, Bangkok 10400, Thailand.
Merlin L. Robb
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA.
Nelson L. Michael
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Peter B. Gilbert
6Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Jerome H. Kim
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Rasmi Thomas
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA.
