15 July 2015
Vol 7, Issue 296
  • Contents

    • Editorial

      • FDA as a catalyst for translation

        The FDA seeks to leverage modern scientific and technological knowledge to accelerate translation.

    • Focus

    • Research Articles

      • Plasticity of the human visual system after retinal gene therapy in patients with Leber’s congenital amaurosis

        Imaging reveals increased structural and functional plasticity in human visual pathways after retinal gene therapy.

      • A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

        The antimalarial drug DSM265 displays activity against blood and liver stages of Plasmodium falciparum and has a long predicted half-life in humans.

      • HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition

        HLA class II modulated the quantity, quality, and efficacy of antibody responses in the RV144 HIV vaccine trial.

    • Editors' Choice

      • Clone wars

        Dynamic expansion of genetically unstable cells drives disease outcome in aplastic anemia.

      • AIREing out the gut

        Loss of AIRE-mediated immune tolerance leads to paneth cell disruption in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

About The Cover

Cover image expansion

ONLINE COVER One Cell at a Time. This image shows a collection of cancer cells, which are grouped into subpopulations by color. Even within groups of the same color, none of the cells are exactly identical, illustrating the importance of single-cell DNA analysis. One cell in the middle, highlighted in red, is shown together with its gene sequence and list of mutations. The 15 July 2015 issue of Science Translational Medicine features an essay by Nicholas Navin, the winner of the 2015 AAAS Martin and Rose Wachtel Cancer Research Award, which is given each year to young researchers who have made important contributions to the field of cancer research. Join us at the National Institutes of Health on 31 July 2015 to hear Dr. Navin present his award-winning research. [CREDIT: N. NAVIN, Y. WANG, J. WATERS/MD ANDERSON CANCER CENTER]