Absence of sperm RNA elements correlates with idiopathic male infertility

Meritxell Jodar; Edward Sendler; Sergey I. Moskovtsev; Clifford L. Librach; Robert Goodrich; Sonja Swanson; Russ Hauser; Michael P. Diamond; Stephen A. Krawetz

doi:10.1126/scitranslmed.aab1287

ReportsINFERTILITY

Absence of sperm RNA elements correlates with idiopathic male infertility

Meritxell Jodar¹,²,
Edward Sendler¹,²,
Sergey I. Moskovtsev³,⁴,
Clifford L. Librach³,⁴,⁵,
Robert Goodrich¹,²,
Sonja Swanson³,
Russ Hauser⁶,⁷,
Michael P. Diamond⁸ and
Stephen A. Krawetz¹,²,*

¹Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
²Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.
³CReATe Fertility Centre, Toronto, Ontario M5G 1N8, Canada.
⁴Department of Obstetrics and Gynaecology, University of Toronto, Ontario M5G 1E2, Canada.
⁵Department of Obstetrics and Gynecology, Women’s College Hospital, Toronto, Ontario M5G 1B1, Canada.
⁶Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
⁷Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
⁸Department of Obstetrics and Gynecology, Georgia Regents University, Augusta, GA 30912, USA.

↵*Corresponding author. E-mail: steve{at}compbio.med.wayne.edu

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Science Translational Medicine 08 Jul 2015:
Vol. 7, Issue 295, pp. 295re6
DOI: 10.1126/scitranslmed.aab1287

Meritxell Jodar

Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.

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Edward Sendler

Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.

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Sergey I. Moskovtsev

CReATe Fertility Centre, Toronto, Ontario M5G 1N8, Canada.Department of Obstetrics and Gynaecology, University of Toronto, Ontario M5G 1E2, Canada.

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Clifford L. Librach

CReATe Fertility Centre, Toronto, Ontario M5G 1N8, Canada.Department of Obstetrics and Gynaecology, University of Toronto, Ontario M5G 1E2, Canada.Department of Obstetrics and Gynecology, Women’s College Hospital, Toronto, Ontario M5G 1B1, Canada.

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Robert Goodrich

Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.

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Sonja Swanson

CReATe Fertility Centre, Toronto, Ontario M5G 1N8, Canada.

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Russ Hauser

Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

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Michael P. Diamond

Department of Obstetrics and Gynecology, Georgia Regents University, Augusta, GA 30912, USA.

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Stephen A. Krawetz

Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.

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For correspondence: steve@compbio.med.wayne.edu

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Absence of sperm RNA elements correlates with idiopathic male infertility

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