The proinflammatory role of HECTD2 in innate immunity and experimental lung injury

Tiffany A. Coon; Alison C. McKelvey; Travis Lear; Shristi Rajbhandari; Sarah R. Dunn; William Connelly; Joe Y. Zhao; SeungHye Han; Yuan Liu; Nathaniel M. Weathington; Bryan J. McVerry; Yingze Zhang; Bill B. Chen

doi:10.1126/scitranslmed.aab3881

Research ArticleLung Disease

The proinflammatory role of HECTD2 in innate immunity and experimental lung injury

Tiffany A. Coon¹,
Alison C. McKelvey¹,
Travis Lear¹,
Shristi Rajbhandari¹,
Sarah R. Dunn¹,
William Connelly¹,
Joe Y. Zhao¹,
SeungHye Han¹,
Yuan Liu¹,
Nathaniel M. Weathington¹,
Bryan J. McVerry¹,
Yingze Zhang¹ and
Bill B. Chen¹,²,*

¹Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.
²Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

↵*Corresponding author. E-mail: chenb{at}upmc.edu

See allHide authors and affiliations

Science Translational Medicine 08 Jul 2015:
Vol. 7, Issue 295, pp. 295ra109
DOI: 10.1126/scitranslmed.aab3881

Tiffany A. Coon

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alison C. McKelvey

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Travis Lear

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shristi Rajbhandari

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sarah R. Dunn

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

William Connelly

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joe Y. Zhao

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

SeungHye Han

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yuan Liu

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nathaniel M. Weathington

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Bryan J. McVerry

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yingze Zhang

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Bill B. Chen

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA.Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: chenb@upmc.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

The proinflammatory role of HECTD2 in innate immunity and experimental lung injury

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools