Contents
01 July 2015
Vol 7, Issue 294
Vol 7, Issue 294
Contents
Editorial
- Know Thy Cells: Improving Biomedical Research Reproducibility
Targeted training and education are critical to change the culture of cell authentication and to accelerate the translation of preclinical research into effective therapies.
Focus
- Vaccination and narcolepsy: Immune link found?
In some children, vaccination against H1N1 influenza spurred production of antibodies to brain receptors linked to narcolepsy (Ahmed et al., this issue).
Research Articles
- Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2
Similarity between influenza nucleoprotein and hypocretin receptor 2 may trigger vaccine-associated narcolepsy.
- Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A–mediated C-terminal dystrophin cleavage fragment
Enterovirus-derived C-terminal dystrophin fragment is a dominant-negative peptide representing a new therapeutic target for viral cardiomyopathy remediation.
- Producing nitric oxide by pulsed electrical discharge in air for portable inhalation therapy
Generating nitric oxide from air by pulsed electrical discharge produces therapeutic levels of nitric oxide for inhalation and provides effective pulmonary vasodilation.
Editors' Choice
- Focusing downstream for safer immunotherapy
CCL3/CCR1 inhibition shows promise for preventing breast cancer metastasis.
- Exercise adaptations: A red herring?
Patients with type 2 diabetes reap benefits from exercise even if they do not exhibit improved cardiorespiratory fitness.
- Sneezing and wheezing: Viruses and bacteria in early childhood wheezy episodes
Bacteria are often associated with wheezing illnesses in high-risk children during the first 3 years of life.
- EPR or no EPR? The billion-dollar question
The enhanced permeability effect is shown to be dependent on tumor histology in canine spontaneous tumors.
About The Cover
ONLINE COVER It's Electric! An iridium electrode's spark generates nitric oxide from ambient air. In this issue, Yu and colleagues packaged this spark into a portable, lightweight device, so that nitric oxide can be easily delivered to patients in emergency rooms or in their own homes. The respiratory device was first tested in lambs with pulmonary hypertension, performing as well as traditional tank-delivered nitric oxide. [CREDIT: B. WILSON/MASSACHUSETTS GENERAL HOSPITAL]