Research ArticleMICROBIOTA

Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis

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Science Translational Medicine  24 Jun 2015:
Vol. 7, Issue 293, pp. 293ra103
DOI: 10.1126/scitranslmed.aab2009

Vitamin B12 contributes to acne by affecting the skin microbiota

Vitamin B12 supplements have been shown to lead to acne development, but the mechanism behind this effect has remained unexplored. Now, Kang et al. show that transcriptional changes in the skin microbiota contribute to vitamin B12–induced acne. Supplementing patients with vitamin B12 reduced the expression of vitamin B12 synthesis genes in Propionibacterium acnes and altered the transcriptome of the skin microbiota, resulting in the production of inflammation-inducing porphyrins. These studies demonstrate a clear link between changes in the skin microbiome and disease pathology.

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