24 June 2015
Vol 7, Issue 293
  • Contents

    • Perspective

      • Developing predictive assays: The phenotypic screening “rule of 3”

        Not all phenotypic assays are created equal; critically evaluating the disease relevance of the assay system, stimulus, and readout can help design the most predictive ones.

    • Research Articles

    • Editors' Choice

      • Screen time

        An interactive, tablet-based screening tool demonstrates predictive value for hearing loss in children.

      • Mixing it up

        The genome reassortment among influenza A viruses that can lead to pandemics may be more common than we thought.

      • Going viral

        A multiplexed assay using a synthetic peptide library enabled population analysis of historical immunization to viral infections in humans.

      • Elucidating the role of C9orf72 mutations in ALS

        Conditional knockdown of C9orf72 in mice does not cause loss of motor function or decrease survival, arguing against a loss-of-function role for C9orf72 in ALS.

      • Genes and lung cancer: Stop YAPping!

        A highly penetrant germline mutation of YAP1 oncogene predisposes to lung adenocarcinoma, and mutation carriers may benefit from increased surveillance.

      • Baby steps in gene therapy

        Teaching the immune system tolerance to a missing protein in neonates improves safety and efficacy of gene replacement therapy.

    • Podcast

About The Cover

Cover image expansion

ONLINE COVER Telltale DNA. Head and neck tumors are often diagnosed at a late stage, and it is difficult to detect recurrent tumors after treatment, because there are no effective biomarkers for this type of cancer. A new study by Wang et al. shows that detection of tumor-associated DNA mutations in patients' plasma and saliva is feasible and accurate, paving the way for early detection of new and recurrent tumors. See also the related Podcast with Agrawal. [CREDIT: E. COOK/JOHNS HOPKINS UNIVERSITY]