Research ArticleAutoimmunity
Transglutaminase 4 as a prostate autoantigen in male subfertility
- Nils Landegren1,2,*,
- Donald Sharon3,4,
- Anthony K. Shum5,
- Imran S. Khan6,
- Kayla J. Fasano6,
- Åsa Hallgren1,2,
- Caroline Kampf7,
- Eva Freyhult8,
- Brita Ardesjö-Lundgren9,
- Mohammad Alimohammadi1,2,10,
- Sandra Rathsman11,
- Jonas F. Ludvigsson12,
- Dan Lundh13,
- Ruben Motrich14,
- Virginia Rivero14,
- Lawrence Fong15,
- Aleksander Giwercman16,
- Jan Gustafsson17,
- Jaakko Perheentupa18,
- Eystein S. Husebye19,
- Mark S. Anderson6,
- Michael Snyder3 and
- Olle Kämpe1,2
- 1Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm SE 171 76, Sweden.
- 2Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala SE 751 85, Sweden.
- 3Department of Genetics, Stanford University, Stanford 94305, CA, USA.
- 4Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
- 5Division of Pulmonary and Critical Care, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
- 6Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.
- 7Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala SE 751 85, Sweden.
- 8Cancer Pharmacology and Computational Medicine, Department of Medical Sciences, Bioinformatics Infrastructure for Life Sciences, Science for Life Laboratory, Uppsala University, Uppsala SE 751 85, Sweden.
- 9Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala SE 750 07, Sweden.
- 10Department of Medical Sciences, Uppsala University, Uppsala SE 751 85, Sweden.
- 11Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro SE 701 85, Sweden.
- 12Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE 171 76, Sweden.
- 13School of Bioscience, University of Skövde, Skövde SE 541 28, Sweden.
- 14Centro de Investigaciones en Bioquímica Clínica e Inmunología, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
- 15University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94115, USA.
- 16Molecular Reproduction Research, Department of Clinical Sciences Malmö, Lund University, Malmö SE 205 02, Sweden.
- 17Department of Women’s and Children’s Health, Uppsala University, Uppsala SE 751 85, Sweden.
- 18The Hospital for Children and Adolescents, University of Helsinki, Helsinki 00029, Finland.
- 19Department of Clinical Science, University of Bergen, and Department of Medicine, Haukeland University Hospital, Bergen 5020, Norway.
- ↵*Corresponding author. E-mail: nils.landegren{at}ki.se
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Science Translational Medicine 17 Jun 2015:
Vol. 7, Issue 292, pp. 292ra101
DOI: 10.1126/scitranslmed.aaa9186
Vol. 7, Issue 292, pp. 292ra101
DOI: 10.1126/scitranslmed.aaa9186
Nils Landegren
Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm SE 171 76, Sweden.Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala SE 751 85, Sweden.
Donald Sharon
Department of Genetics, Stanford University, Stanford 94305, CA, USA.Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Anthony K. Shum
Division of Pulmonary and Critical Care, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Imran S. Khan
Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.
Kayla J. Fasano
Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.
Åsa Hallgren
Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm SE 171 76, Sweden.Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala SE 751 85, Sweden.
Caroline Kampf
Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala SE 751 85, Sweden.
Eva Freyhult
Cancer Pharmacology and Computational Medicine, Department of Medical Sciences, Bioinformatics Infrastructure for Life Sciences, Science for Life Laboratory, Uppsala University, Uppsala SE 751 85, Sweden.
Brita Ardesjö-Lundgren
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala SE 750 07, Sweden.
Mohammad Alimohammadi
Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm SE 171 76, Sweden.Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala SE 751 85, Sweden.Department of Medical Sciences, Uppsala University, Uppsala SE 751 85, Sweden.
Sandra Rathsman
Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro SE 701 85, Sweden.
Jonas F. Ludvigsson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE 171 76, Sweden.
Dan Lundh
School of Bioscience, University of Skövde, Skövde SE 541 28, Sweden.
Ruben Motrich
Centro de Investigaciones en Bioquímica Clínica e Inmunología, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
Virginia Rivero
Centro de Investigaciones en Bioquímica Clínica e Inmunología, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
Lawrence Fong
University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94115, USA.
Aleksander Giwercman
Molecular Reproduction Research, Department of Clinical Sciences Malmö, Lund University, Malmö SE 205 02, Sweden.
Jan Gustafsson
Department of Women’s and Children’s Health, Uppsala University, Uppsala SE 751 85, Sweden.
Jaakko Perheentupa
The Hospital for Children and Adolescents, University of Helsinki, Helsinki 00029, Finland.
Eystein S. Husebye
Department of Clinical Science, University of Bergen, and Department of Medicine, Haukeland University Hospital, Bergen 5020, Norway.
Mark S. Anderson
Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.
Michael Snyder
Department of Genetics, Stanford University, Stanford 94305, CA, USA.
Olle Kämpe
Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm SE 171 76, Sweden.Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala SE 751 85, Sweden.
