FocusCARDIOVASCULAR AGING

Cardiac aging: Send in the vinculin reinforcements

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Science Translational Medicine  17 Jun 2015:
Vol. 7, Issue 292, pp. 292fs26
DOI: 10.1126/scitranslmed.aab3391

Figures

  • Fig. 1 Mechanisms of cytoskeletal reinforcement.

    Vinculin aids in anchoring myofibrils and facilitating longitudinal force transmission between myocytes. Advanced age is associated with increased levels of cardiac vinculin. Vinculin overexpression results in cytoskeletal reinforcement, causes myofibril reordering, and improves cardiac performance in flies. Further, cardiac vinculin overexpression extends life span. These findings demonstrate the potential role of vinculin overexpression as a beneficial cardiac aging response. Figure adapted from Kaushik et al. (3), with permission.

    CREDIT: V. ALTOUNIAN/SCIENCE TRANSLATIONAL MEDICINE

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