17 June 2015
Vol 7, Issue 292

About The Cover

Cover image expansion

ONLINE COVER Young at Heart. As we age, the heart figures out ways to keep healthy and beat normally, despite minimal regenerative capabilities. To uncover how the heart does this, Kaushik et al. characterized the proteomes of young and old rhesus monkeys and rats, and found that such age-associated remodeling is linked to the cardiomyocyte cytoskeleton; specifically, the protein vinculin. Vinculin overexpression in flies further revealed its beneficial effects on the heart, as well as its ability to prolong life span. See the related Focus by DeLeon-Pennell and Lindsey. [CREDIT: P. SVARC/CORBIS]