Research ArticleCancer

α-Enolase–binding peptide enhances drug delivery efficiency and therapeutic efficacy against colorectal cancer

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Science Translational Medicine  03 Jun 2015:
Vol. 7, Issue 290, pp. 290ra91
DOI: 10.1126/scitranslmed.aaa9391

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Direct delivery

Standard chemotherapies for cancer are generally effective for killing cancer cells, but they cannot be delivered precisely to their targets. As a result, healthy cells get damaged or killed as well, causing severe side effects and limiting the amount of drugs that can be applied against the cancer. Wu et al. used a phage display peptide library to identify peptides that could help with targeted delivery of drugs to colorectal cancer cells and minimize damage to healthy tissues. The authors identified a peptide targeting a protein called α-enolase and showed that nanoparticles coated with this peptide could effectively deliver two different chemotherapeutics to colorectal cancer cells and extend survival in mouse models of the disease.

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