A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

Fabiano Oliveira; Edgar Rowton; Hamide Aslan; Regis Gomes; Philip A. Castrovinci; Patricia H. Alvarenga; Maha Abdeladhim; Clarissa Teixeira; Claudio Meneses; Lindsey T. Kleeman; Anderson B. Guimarães-Costa; Tobin E. Rowland; Dana Gilmore; Seydou Doumbia; Steven G. Reed; Phillip G. Lawyer; John F. Andersen; Shaden Kamhawi; Jesus G. Valenzuela

doi:10.1126/scitranslmed.aaa3043

Research ArticleLeishmaniasis

A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

Fabiano Oliveira¹,
Edgar Rowton²,
Hamide Aslan¹,*,
Regis Gomes¹,³,
Philip A. Castrovinci¹,
Patricia H. Alvarenga⁴,⁵,
Maha Abdeladhim¹,
Clarissa Teixeira¹,³,
Claudio Meneses¹,
Lindsey T. Kleeman¹,
Anderson B. Guimarães-Costa¹,
Tobin E. Rowland²,
Dana Gilmore¹,
Seydou Doumbia⁶,
Steven G. Reed⁷,
Phillip G. Lawyer²,
John F. Andersen⁸,
Shaden Kamhawi¹,† and
Jesus G. Valenzuela¹,†

¹Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
²Department of Entomology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
³Centro de Pesquisas Gonçalo Moniz (CPqGM)–Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia 40296-710, Brazil.
⁴Laboratório de Bioquímica de Resposta ao Estresse, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
⁵Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
⁶Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako 1805, Mali.
⁷Infectious Disease Research Institute, Seattle, WA 98102, USA.
⁸Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

↵†Corresponding author. E-mail: jvalenzuela{at}niaid.nih.gov (J.G.V.); skamhawi{at}niaid.nih.gov (S.K.)

↵* Present address: Nursing Department, Faculty of Health Science, Selahaddin Eyyubi University, Diyarbakir, Turkey.

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Science Translational Medicine 03 Jun 2015:
Vol. 7, Issue 290, pp. 290ra90
DOI: 10.1126/scitranslmed.aaa3043

Fabiano Oliveira

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Edgar Rowton

2Department of Entomology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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Hamide Aslan

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Regis Gomes

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

3Centro de Pesquisas Gonçalo Moniz (CPqGM)–Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia 40296-710, Brazil.

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Philip A. Castrovinci

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Patricia H. Alvarenga

4Laboratório de Bioquímica de Resposta ao Estresse, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

5Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

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Maha Abdeladhim

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Clarissa Teixeira

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

3Centro de Pesquisas Gonçalo Moniz (CPqGM)–Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia 40296-710, Brazil.

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Claudio Meneses

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Lindsey T. Kleeman

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Anderson B. Guimarães-Costa

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Tobin E. Rowland

2Department of Entomology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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Dana Gilmore

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Seydou Doumbia

6Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako 1805, Mali.

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Steven G. Reed

7Infectious Disease Research Institute, Seattle, WA 98102, USA.

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Phillip G. Lawyer

2Department of Entomology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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John F. Andersen

8Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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Shaden Kamhawi

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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For correspondence: jvalenzuela@niaid.nih.gov skamhawi@niaid.nih.gov

Jesus G. Valenzuela

1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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For correspondence: jvalenzuela@niaid.nih.gov skamhawi@niaid.nih.gov

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A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

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