Research ArticleLeishmaniasis

A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

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Science Translational Medicine  03 Jun 2015:
Vol. 7, Issue 290, pp. 290ra90
DOI: 10.1126/scitranslmed.aaa3043

Leishmania vaccine targets the messenger

The old adage “Don’t kill the messenger” may not hold true when vaccinating against leishmaniasis. Oliveira et al. demonstrate that a vaccine against sand fly salivary protein can protect nonhuman primate from leishmania infection. Leishmaniasis is transmitted by the bite of infected phlebotomine sand flies, which also transfer some of their saliva with the bite. Most macaques vaccinated against PdSP15, a sand fly salivary protein, had decreased parasite burden after induction of cutaneous leishmaniasis initiated by infected bites. Moreover, people exposed to sand fly bites developed an immune response to PdSP15 as well, suggesting that this approach may be translatable to humans.

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