Research ArticleEbola virus

A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity

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Science Translational Medicine  03 Jun 2015:
Vol. 7, Issue 290, pp. 290ra89
DOI: 10.1126/scitranslmed.aaa5597

Drug repurposing for Ebola virus

The recent Ebola virus outbreak has highlighted the lack of therapies for filovirus infection. FDA-approved drugs serve as a source of medications with a proven safety record. Johansen et al. have now screened about 2600 FDA-approved drugs and molecular probes and found 80 that have some efficacy against Zaire ebolavirus in vitro. These drugs were mechanistically diverse, and several drugs, including a calcium channel blocker and an antidepressant, could protect against infection in a mouse model. Although new therapy development is ongoing, these repurposed drugs can rapidly move to human testing and may serve on the frontline against Ebolavirus infection.

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