Contents
Vol 7, Issue 290
Contents
Perspectives
- Global implementation of genomic medicine: We are not alone
Human-genomics programs work together worldwide to speed the translation of genomic medicine to the clinic.
- Nano-antidotes for drug overdose and poisoning
Nanotechnologies for detoxification—nano-antidotes—are rising to the challenge of the growing overdose epidemic.
Research Articles
- Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients
Citrullinated peptide-exposed DCs induced immune regulatory effects in HLA risk genotype–positive RA patients.
- Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia
Reduction of vascular RGS5 causes hypertension and preeclampsia, which can be reversed by PPAR agonist treatment in mouse models.
- A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity
Several FDA-approved drugs, including bepridil and sertraline, may be therapeutics against filovirus infections.
- A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates
Immunity to sand fly salivary protein correlates to protection against cutaneous leishmaniasis in rhesus macaques.
- α-Enolase–binding peptide enhances drug delivery efficiency and therapeutic efficacy against colorectal cancer
α-Enolase–targeted lipid nanoparticles containing chemotherapeutic drugs are effective for the treatment of colorectal cancer.
- Drug-induced regeneration in adult mice
The capacity for regeneration can be elicited in adult mice by drug-induced stabilization of hypoxia-inducible factor 1α (HIF-1α) protein.
Editors' Choice
- Stem cells in gels
Transplanting stem cells with a hyaluronan and methylcellulose hydrogel improves cell survival and integration in the retina and brain.
- Toward personalized medicine for the tiniest patients
Continuous monitoring of cerebrovascular reactivity may guide hemodynamic management in preterm infants.
- TERT, cancer, scissors
In vivo studies reveal a clinically relevant connection between spliceosome mutations, telomere erosion, and cancer.
- Why some fish don’t tan
Discovery of a UV-protective biosynthetic pathway in vertebrates might drive development of a small-molecule sunscreen.
- Original antigenic sin strikes again?
Early exposure to an H1 subtype influenza virus may decrease immunity against current H1 viruses in middle-aged adults.
