Contents
Vol 7, Issue 289
Contents
Editorial
- Engineering precision
Engineering sciences will play a vital role in delivering precision medicine to the bedside.
Focus
- Research in academic medical centers: Two threats to sustainable support
Reductions in federal support and clinical revenue jeopardize biomedical research and, in turn, clinical medicine.
Research Articles
- Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs
Hepatocyte-targeted InsB9–23 gene transfer protects from type 1 diabetes by inducing antigen-specific regulatory T cells.
- A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: Preclinical activity and safety in nonhuman primates
MGD006, a CD3xCD123 bispecific DART molecule intended for AML treatment, shows anticancer activity in mouse model and favorable pharmacodynamic and safety profile in nonhuman primates.
- Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates
With the use of digital genetic amplifiers and logic gates, prototype whole-cell biosensors can be engineered to detect diagnostic biomarkers in complex human clinical samples.
- Programmable probiotics for detection of cancer in urine
Probiotics programmed to generate specific metabolites traffic from the gut to tumors and enable cancer detection through the urine.
- Shaping mycolactone for therapeutic use against inflammatory disorders
A synthetic mycobacterial macrolide mycolactone decreases skin inflammation and inflammatory pain.
- SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma
SLC7A11, the catalytic subunit of the cystine/glutamate antiporter, System xc− (SXC), is up-regulated in a subpopulation of patient gliomas, where it is responsible for excitotoxic glutamate release, accelerated tumor growth, and tumor-associated seizures.
Editors' Choice
- A sticky (synergistic) situation
Metabolomics identifies polyamines as a link between bacterial biofilms and colon cancer.
- Colorectal cancer in miniature
Patient-derived tumor cell lines can be reliably generated as the basis of in vitro drug screens and personalized treatment plans.
- Fast and furious: Why all CARs are not made equal
4-1BB can mitigate CAR endodomain-induced T cell exhaustion and prolong T cell survival.
- Convergence of stroke and Alzheimer's neurovascular research
Edaravone, a small-molecule drug already in use outside the United States for stroke, reverses Alzheimer's pathology in a transgenic mouse model.
- Heart attack on a plate
Carefully engineered arrays of human cardiac cells allow high-throughput drug screening.
- A graphene security blanket
Mesenchymal stem cells clinging to graphene oxide microflakes display enhanced survival and engraftment in heart tissue.
Erratum
